Human CD69 (N-8His, HEK293)/人CD69蛋白(N-8His, HEK293)
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货号：A2925293同义名：
重组人CD69蛋白(N-8His, HEK293)
/ Recombinant Human CD69 (N-8His, HEK293); Early activation antigen CD69
Recombinant Human CD69 (N-8His, HEK293)是人源蛋白，在HEK293细胞中表达，带有N端8His标签。该蛋白为早期活化抗原CD69，属于II型跨膜糖蛋白，参与免疫细胞迁移、炎症反应、T细胞记忆及体液免疫应答，主要表达于活化的T细胞、NK细胞、树突状细胞等，可调控多种趋化因子及其受体的表达，影响免疫细胞的迁移与功能。
Human CD69 (N-8His, HEK293)/人CD69蛋白(N-8His, HEK293) 化学结构 CAS号：N/A
Human CD69 (N-8His, HEK293)/人CD69蛋白(N-8His, HEK293) 3D分子结构 CAS号：N/A
Human CD69 (N-8His, HEK293)/人CD69蛋白(N-8His, HEK293) 质控信息
Human CD69 (N-8His, HEK293)/人CD69蛋白(N-8His, HEK293) 生物活性
描述
Human Early Activation Antigen CD69 (CD69) is a type 2 transmembrane glycoprotein in the C-type lectin family. It plays roles in immune cell trafficking, inflammation, T cell memory, and humoral immune responses. CD69 is expressed on the cell surface as an approximately 60 kDa disulfide-linked homodimer. It is found on CD4+ T cells, CD8+ T cells, NK cells, NKT cells, gamma delta cells dendritic cells (DC) and is up-regulated on activated T cells and DC. Ligation of CD69 on DC induces IL2 production, leading to T cell proliferation. CD69 is important for the homing of CD4+ T cells and plasmablasts to the bone marrow but inhibits the migration of dermal DC to draining lymph nodes. It supports the expression of multiple chemokines and chemokine receptors but suppresses the expression of others. It associates with and negatively regulates S1P1 expression on DC and CD4+ T cells, resulting in a decreased chemotactic response to S1P. The direct interaction of CD69 with Galectin-1 contributes to the ability of CD69 to limit Th17 mediated inflamamtion while supporting the differentiation of regulatory T cells.
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human CD69 (N-8His, HEK293)/人CD69蛋白(N-8His, HEK293) 技术信息
CAS号
N/A
分子量
16.9 KDa
SMILES Code
NONE
别名
重组人CD69蛋白(N-8His, HEK293)
;Recombinant Human CD69 (N-8His, HEK293); Early activation antigen CD69; Activation inducer molecule; AIM; BL-AC/P26; C-type lectin domain family 2 member C; EA1; Early T-cell activation antigen p60; GP32/28; Leukocyte surface antigen Leu-23; MLR-3; CD69; CLEC2C
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Human CD69 (N-8His, HEK293)/人CD69蛋白(N-8His, HEK293)
|Human CD69 (N-8His, HEK293)/人CD69蛋白(N-8His, HEK293)
| 重组人CD69蛋白(N-8His, HEK293)
| Recombinant Human CD69 (N-8His, HEK293)
| Early activation antigen CD69
| Activation inducer molecule
| AIM
| BL-AC/P26
| C-type lectin domain family 2 member C
| EA1
| Early T-cell activation antigen p60
| GP32/28
| Leukocyte surface antigen Leu-23
| MLR-3
| CD69
| CLEC2C
| N/A
| Epithelial cell CD Proteins
| NK Cell CD Proteins
| Stem Cell CD Proteins
| Platelet CD Proteins
| Pattern Recognition Receptors
| B Cell CD Proteins
| Human CD69 (N-8His, HEK293)/人CD69蛋白(N-8His, HEK293) 纯度/质量文件
| Human CD69 (N-8His, HEK293)/人CD69蛋白(N-8His, HEK293) 生物活性
| Human CD69 (N-8His, HEK293)/人CD69蛋白(N-8His, HEK293) 技术信息
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