Recombinant Human CD44 (C-Fc, HEK293)是人源CD44蛋白，在人源细胞中表达，带有C-Fc标签。该蛋白是透明质酸的细胞表面受体，还可与骨桥蛋白、胶原蛋白及基质金属蛋白酶等其他配体相互作用，具有多种剪接异构体。其表达水平与非小细胞肺癌复发相关，并在炎症性疾病中发挥重要作用，缺失会导致严重肝损伤，参与淋巴细胞与内皮细胞黏附及促炎因子释放。
Human CD44 (C-Fc, HEK293)/人CD44蛋白(C-Fc, HEK293) 化学结构 CAS号：N/A
Human CD44 (C-Fc, HEK293)/人CD44蛋白(C-Fc, HEK293) 3D分子结构 CAS号：N/A
Human CD44 (C-Fc, HEK293)/人CD44蛋白(C-Fc, HEK293) 质控信息
Human CD44 (C-Fc, HEK293)/人CD44蛋白(C-Fc, HEK293) 生物活性
描述
CD44 is a cell-surface receptor for hyaluronic acid and also interacts with other ligands, such as osteopontin, collagens, and matrix metalloproteinases. A large number of CD44 isoforms can be generated by the insertion of different combinations of at least nine exons. Increased CD44 antigen is associated with relapses in non-small cell lung cancers. Furthermore, an increasing quantity of evidence suggests that CD44 has various functions related to inflammatory disease. CD44 deficiency induces severe liver injury. CD44-hyaluronate mediates in lymphocyte T and monocyte adhesion to the endothelium, stimulates proinflammatory cytokine release from macrophages and participates in dedifferentiation phenotype of smooth muscle cells from contractile state to synthetic one.
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human CD44 (C-Fc, HEK293)/人CD44蛋白(C-Fc, HEK293) 技术信息
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