Human CD30 (C-Fc, HEK293)/人CD30蛋白(C-Fc, HEK293)
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货号：A2925106同义名：
重组人CD30蛋白(C-Fc, HEK293)
/ Recombinant Human CD30 (C-Fc, HEK293); Tumor necrosis factor receptor superfamily member 8
Recombinant Human CD30 (C-Fc, HEK293)是人类来源的重组蛋白，在HEK293人源细胞中表达，带有C端Fc标签。该蛋白即CD30（又称TNFRSF8），属于肿瘤坏死因子受体家族的细胞膜蛋白，调控细胞增殖/凋亡及抗体应答，主要表达于活化的T、B细胞。其异常表达与系统性肥大细胞增多症、间变性大细胞淋巴瘤及经典霍奇金淋巴瘤的发病相关，也是抗体药物偶联治疗的重要靶标。
Human CD30 (C-Fc, HEK293)/人CD30蛋白(C-Fc, HEK293) 化学结构 CAS号：N/A
Human CD30 (C-Fc, HEK293)/人CD30蛋白(C-Fc, HEK293) 3D分子结构 CAS号：N/A
Human CD30 (C-Fc, HEK293)/人CD30蛋白(C-Fc, HEK293) 质控信息
Human CD30 (C-Fc, HEK293)/人CD30蛋白(C-Fc, HEK293) 生物活性
描述
CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family, which regulates proliferation/apoptosis and antibody responses. CD30 is expressed by activated, but not by resting, T and B cells. Aberrant expression of CD30 by mastocytosis mast cells and interaction with its ligand CD30L (CD153) appears to play an important role in the pathogenesis and clinical presentation of systemic mastocytosis. CD30 has been considered as a specific diagnostic biomarker of anaplastic large cell lymphoma (ALCL) and classical Hodgkin lymphoma (cHL). CD30 is also a biomarker used for targeted therapy by an antibody–drug conjugate.
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human CD30 (C-Fc, HEK293)/人CD30蛋白(C-Fc, HEK293) 技术信息
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