货号:A2925284
同义名:
重组人CD24蛋白(S44T, C-Fc, HEK293)
/ Recombinant Human CD24 (S44T, C-Fc, HEK293); Signal transducer CD24
Recombinant Human CD24 (S44T, C-Fc, HEK293)是人类来源的重组蛋白,在HEK293人源细胞中表达,带有C-Fc标签。该蛋白为信号转导分子CD24的突变体,是一种高度糖基化的GPI锚定唾液酸蛋白,广泛表达于B系细胞、粒细胞、上皮细胞、神经元及肿瘤细胞等,参与免疫耐受诱导、T细胞共刺激及炎症调控,通过与Siglec10及DAMPs形成复合物发挥抗炎保护作用。


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| 描述 | Signal Transducer CD24 is a heavily and variably glycosylated GPI-linked sialoprotein. Human CD24 is expressed on B lineage cells and granulocytes, on epithelial, neuronal, and muscle cells, and on a range of tumor cells. CD24 expression is regulated during lineage development and with the activation of various cell types. Antibody crosslinking of CD24 enhances the induction of apoptosis in B and T lymphocytes which contributes to negative selection and the induction of immune tolerance. CD24 on antigen presenting cells cooperates with B7 molecules in the costimulation of T cells. CD24 associates in cis with Siglec10 and with the danger-associated molecules HMGB1, HSP70, or HSP90 which are released from necrotic or damaged cells. Formation of these ternary complexes fills a protective role: the resulting Siglec10 signaling inhibits inflammatory responses that are otherwise induced by extracellular DAMPs. |
| 蛋白种属 | Human |
| 表达系统 | Human Cells |
| 标签 | C-Fc |
| 蛋白表达区间 | Ser27-Gly59(Ser44Thr) |
| 蛋白编号 | P25063 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 干粉 |
| 剂型描述 | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。 分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 29.8 KDa |
| SMILES Code | NONE |
| 别名 | 重组人CD24蛋白(S44T, C-Fc, HEK293) ;Recombinant Human CD24 (S44T, C-Fc, HEK293); Signal transducer CD24; Small cell lung carcinoma cluster 4 antigen; CD24; CD24A |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Sealed in dry, store in freezer, under -20°C |
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