Recombinant Human CD207 (N-6His, HEK293)是人源蛋白，在HEK293细胞中表达，带有N端6×His标签。该产品为Langerin（CD207），是一种II型跨膜糖蛋白，属于C型凝集素结构域家族K成员，是朗格汉斯细胞的标志性分子，参与Birbeck颗粒形成，可介导甘露糖、N-乙酰葡糖胺和岩藻糖等非肽类抗原的内吞，对免疫调节起重要作用。
Human CD207 (N-6His, HEK293)/人CD207蛋白(N-6His, HEK293) 化学结构 CAS号：N/A
Human CD207 (N-6His, HEK293)/人CD207蛋白(N-6His, HEK293) 3D分子结构 CAS号：N/A
Human CD207 (N-6His, HEK293)/人CD207蛋白(N-6His, HEK293) 质控信息
Human CD207 (N-6His, HEK293)/人CD207蛋白(N-6His, HEK293) 生物活性
描述
Langerin (CD207) is a type II transmembrane glycoprotein which is member K of the C-type lectin domain family. Langerin is used as a marker for Langerhans cells (LCs) which represent the immature dendritic cells in the epidermis. Langerin is necessary and sufficient for Birbeck granule formation. Human langerin sequence contains a 43 aa cytoplasmic domain, a 21 aa transmembrane domain and a 264 aa extracellular domain (ECD) that contains a coiled-coil domain and a single C-type lectin domain. Human langerin shares 68%, 62%, 71% aa identity with mouse, rat and bovine langerin ECD, respectively. Trimerization greatly increases the lectin binding affinity. Langerin internalizes endogenous proteins such as type I procollagen. Internalization by LC is thought to lead to suppression of self reactions. Langerin also mediates endocytosis of non-peptide antigens containing mannose, N-acetyl glucosamine and fucose that are expressed by mycobacteria and fungae.
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human CD207 (N-6His, HEK293)/人CD207蛋白(N-6His, HEK293) 技术信息
CAS号
N/A
分子量
31.5 KDa
SMILES Code
NONE
别名
重组人CD207蛋白(N-6His, HEK293)
;Recombinant Human CD207 (N-6His, HEK293); CD207 antigen; langerin; CD207; C-type lectin domain family 4 member K
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Human CD207 (N-6His, HEK293)/人CD207蛋白(N-6His, HEK293)
|Human CD207 (N-6His, HEK293)/人CD207蛋白(N-6His, HEK293)
| 重组人CD207蛋白(N-6His, HEK293)
| Recombinant Human CD207 (N-6His, HEK293)
| CD207 antigen
| langerin
| CD207
| C-type lectin domain family 4 member K
| N/A
| Dendritic Cell CD Proteins
| Pattern Recognition Receptors
| Human CD207 (N-6His, HEK293)/人CD207蛋白(N-6His, HEK293) 纯度/质量文件
| Human CD207 (N-6His, HEK293)/人CD207蛋白(N-6His, HEK293) 生物活性
| Human CD207 (N-6His, HEK293)/人CD207蛋白(N-6His, HEK293) 技术信息
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