Human CD16a (V176, C-6His, HEK293)/人CD16a蛋白(V176, C-6His, HEK293) 质控信息
Human CD16a (V176, C-6His, HEK293)/人CD16a蛋白(V176, C-6His, HEK293) 生物活性
描述
Receptors for the Fc region of immunoglobin G (FcγR) are divided into three classes and FcγRIII is a multifunctional, low/intermediate affinity receptor. In humans, FcγRIII is expressed as two distinct forms (FcγRIIIA and FcγRIIIB) that are encoded by two different but highly homologous genes in a cell type-specific manner. FcγRIIIB is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas FcγRIIIA is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed by a subset of T lymphocytes, natural killer (NK) cells, monocytes, and macrophages. The FcγRIIIA receptor is involved in phagocytosis, secretion of enzymes, inflammatory mediators, antibody-dependent cellular cytotoxicity (ADCC), mast cell degranulation, and clearance of immune complexes. FcγRIIIA has an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and delivers an activation signal in the immune responses. Aberrant expression or mutations in this gene is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia. In humans, it is a 50 -70 kD type I transmembrane activating receptor. The FcγRIIIA cDNA encodes 254 amino acid including a 16aa signal sequence, 191 amino acid ECD with two C2-type Ig-like domains, five potential N-glycosylation sites, a 22 amino acid transmembrane sequence and a 25 amino acid cytoplasmic domain.
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human CD16a (V176, C-6His, HEK293)/人CD16a蛋白(V176, C-6His, HEK293) 技术信息
CAS号
N/A
分子量
22.68 KDa
SMILES Code
NONE
别名
重组人CD16a蛋白(V176, C-6His, HEK293)
;Recombinant Human CD16a (V176, C-6His, HEK293); Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A; CD16a Antigen; Fc-Gamma RIII-Alpha; Fc-Gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcR-10; IgG Fc Receptor III-2; CD16a; FCGR3A; CD16A; FCG3; FCGR3; IGFR3
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Human CD16a (V176, C-6His, HEK293)/人CD16a蛋白(V176, C-6His, HEK293)
|Human CD16a (V176, C-6His, HEK293)/人CD16a蛋白(V176, C-6His, HEK293)
| 重组人CD16a蛋白(V176, C-6His, HEK293)
| Recombinant Human CD16a (V176, C-6His, HEK293)
| Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A
| CD16a Antigen
| Fc-Gamma RIII-Alpha
| Fc-Gamma RIII
| Fc-gamma RIIIa
| FcRIII
| FcRIIIa
| FcR-10
| IgG Fc Receptor III-2
| CD16a
| FCGR3A
| CD16A
| FCG3
| FCGR3
| IGFR3
| N/A
| Epithelial cell CD Proteins
| Platelet CD Proteins
| B Cell CD Proteins
| Human CD16a (V176, C-6His, HEK293)/人CD16a蛋白(V176, C-6His, HEK293) 纯度/质量文件
| Human CD16a (V176, C-6His, HEK293)/人CD16a蛋白(V176, C-6His, HEK293) 生物活性
| Human CD16a (V176, C-6His, HEK293)/人CD16a蛋白(V176, C-6His, HEK293) 技术信息
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