Human CD16a (F176,C-6His)/人CD16a蛋白(HEK293, C-6His)
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货号：A2900741同义名：
重组人CD16a蛋白(HEK293, C-6His)
/ Recombinant Human CD16a (F176,C-6His); Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A
Recombinant Human CD16a (F176,C-6His)是人类重组CD16a (F176位点，C端6His标签)蛋白，在人源细胞中表达，带有C端6His标签。该蛋白为FcγRIIIA，属于低/中等亲和力Fcγ受体，参与抗体依赖性细胞毒性（ADCC）、吞噬作用及免疫复合物清除，是介导免疫应答的重要激活型受体，与病毒感染、自身免疫疾病等密切相关。
Human CD16a (F176,C-6His)/人CD16a蛋白(HEK293, C-6His) 化学结构 CAS号：N/A
Human CD16a (F176,C-6His)/人CD16a蛋白(HEK293, C-6His) 3D分子结构 CAS号：N/A
Human CD16a (F176,C-6His)/人CD16a蛋白(HEK293, C-6His) 质控信息
Human CD16a (F176,C-6His)/人CD16a蛋白(HEK293, C-6His) 生物活性
描述
Receptors for the Fc region of immunoglobin G (FcγR) are divided into three classes and FcγRIII is a multifunctional, low/intermediate affinity receptor. In humans, FcγRIII is expressed as two distinct forms (FcγRIIIA and FcγRIIIB) that are encoded by two different but highly homologous genes in a cell type-specific manner. FcγRIIIB is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas FcγRIIIA is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed by a subset of T lymphocytes, natural killer (NK) cells, monocytes, and macrophages. The FcγRIIIA receptor is involved in phagocytosis, secretion of enzymes, inflammatory mediators, antibody-dependent cellular cytotoxicity (ADCC), mast cell degranulation, and clearance of immune complexes. FcγRIIIA has an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and delivers an activation signal in the immune responses. Aberrant expression or mutations in this gene is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia. In humans, it is a 50 -70 kD type I transmembrane activating receptor.
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human CD16a (F176,C-6His)/人CD16a蛋白(HEK293, C-6His) 技术信息
CAS号
N/A
分子量
22.7 KDa
SMILES Code
NONE
别名
重组人CD16a蛋白(HEK293, C-6His)
;Recombinant Human CD16a (F176,C-6His); Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A; CD16a Antigen; Fc-Gamma RIII-Alpha; Fc-Gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcR-10; IgG Fc Receptor III-2; CD16a; FCGR3A; CD16A; FCG3; FCGR3; IGFR3
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Human CD16a (F176,C-6His)/人CD16a蛋白(HEK293, C-6His)
|Human CD16a (F176,C-6His)/人CD16a蛋白(HEK293, C-6His)
| 重组人CD16a蛋白(HEK293, C-6His)
| Recombinant Human CD16a (F176,C-6His)
| Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A
| CD16a Antigen
| Fc-Gamma RIII-Alpha
| Fc-Gamma RIII
| Fc-gamma RIIIa
| FcRIII
| FcRIIIa
| FcR-10
| IgG Fc Receptor III-2
| CD16a
| FCGR3A
| CD16A
| FCG3
| FCGR3
| IGFR3
| N/A
| Dendritic Cell CD Proteins
| Macrophage CD Proteins
| Monocyte CD Proteins
| NK Cell CD Proteins
| T Cell CD Proteins
| Fc-gamma Receptor
| Immune Checkpoint Proteins
| Receptor Proteins
| Human CD16a (F176,C-6His)/人CD16a蛋白(HEK293, C-6His) 纯度/质量文件
| Human CD16a (F176,C-6His)/人CD16a蛋白(HEK293, C-6His) 生物活性
| Human CD16a (F176,C-6His)/人CD16a蛋白(HEK293, C-6His) 技术信息
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