Human CCL11 (E.coli)/人CCL11蛋白(Tag free, E.coli)
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货号：A2924046同义名：
重组人CCL11蛋白(Tag free, E.coli)
/ Recombinant Human CCL11 (E.coli); Eotaxin
Recombinant Human CCL11 (E.coli)是人源蛋白，在大肠杆菌中表达，为无标签蛋白。该蛋白即C-C基序趋化因子11，属于细胞间β（趋化因子CC）家族分泌蛋白，可选择性招募嗜酸性粒细胞，介导过敏炎症反应，通过与CCR2、CCR3和CCR5等G蛋白偶联受体结合发挥作用，对中性粒细胞和单核细胞无活性。
Human CCL11 (E.coli)/人CCL11蛋白(Tag free, E.coli) 化学结构 CAS号：N/A
Human CCL11 (E.coli)/人CCL11蛋白(Tag free, E.coli) 3D分子结构 CAS号：N/A
Human CCL11 (E.coli)/人CCL11蛋白(Tag free, E.coli) 质控信息
Human CCL11 (E.coli)/人CCL11蛋白(Tag free, E.coli) 生物活性
描述
C-C Motif Chemokine 11 (CCL11) is a secreted protein that belongs to the intercrine beta (chemokine CC) family. In response to the presence of allergens, CCL11 selectively recruits eosinophils, a prominent feature of allergic inflammatory reactions. The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for CCL11 include CCR2, CCR3 and CCR5. However, it has been found that CCL11 has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3.
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human CCL11 (E.coli)/人CCL11蛋白(Tag free, E.coli) 技术信息
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