货号:A2925186
同义名:
重组人BTN2A1蛋白(C-6His, HEK293)
/ Recombinant Human BTN2A1 (C-6His, HEK293); Butyrophilin subfamily 2 member A1
Recombinant Human BTN2A1 (C-6His, HEK293)是人源蛋白,在HEK293细胞中表达,带有C端6His标签。该蛋白为Butyrophilin 2A1重组蛋白,是一种广泛表达的I型跨膜糖蛋白,包含两个免疫球蛋白样结构域,参与与DCSIGN的相互作用,其多态性与代谢综合征、II型糖尿病、慢性肾病和高血压相关。


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| 描述 | Butyrophilin 2A1 (BTN2A1) is an approximately widely expressed and variably glycosylated type I transmembrane glycoprotein. Mature human Butyrophilin 2A1 consisits of a 220 amino acid (aa) extracellular domain with two immunoglobulin-like domains, a 21 aa transmembrane segment, and a 258 aa cytoplasmic domain. Alternative splicing generates additional isoforms of human Butyrophilin 2A1 that lack the first Ig like domain or transmembrane segment as well as isoforms with substitutions and deletions in the cytoplasmic region. BTN2A1 is widely expressed including on colonic epithelial cells, on immune cells, and in milk fat globules. It binds to the C-type lectin DCSIGN on monocytederived dendritic cells, and this interaction can be blocked by soluble gp130 from HIV. The polymorphism of BTN2A1 has been associated with metabolic syndrome, type II diabetes mellitus, chronic kidney disease, and hypertension. |
| 蛋白种属 | Human |
| 表达系统 | Human Cells |
| 标签 | C-6His |
| 蛋白表达区间 | Gln29-Ala248 |
| 蛋白编号 | Q7KYR7-2 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 干粉 |
| 剂型描述 | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。 分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 25.4 KDa |
| SMILES Code | NONE |
| 别名 | 重组人BTN2A1蛋白(C-6His, HEK293) ;Recombinant Human BTN2A1 (C-6His, HEK293); Butyrophilin subfamily 2 member A1; BTN2A1; BT2.1; BTF1 |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Sealed in dry, store in freezer, under -20°C |
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