货号:A2925580
同义名:
重组人BTN1A1蛋白(C-Fc, HEK293)
/ Recombinant Human BTN1A1 (C-Fc, HEK293); Butyrophilin Subfamily 1 Member A1
Recombinant Human BTN1A1 (C-Fc, HEK293) 是人源Butyrophilin Subfamily 1 Member A1 (BTN1A1) 蛋白,在人源细胞(HEK293)中表达,带有C端Fc标签。该蛋白是乳汁中脂肪滴的主要关联蛋白,属于免疫球蛋白超家族,定位在MHC I类基因区,可通过抑制CD4和CD8 T细胞活化、代谢及IL2、IFNG分泌发挥免疫调节作用。


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| 描述 | Butyrophilin Subfamily 1 Member A1 (BTN1A1) is the major protein associated with fat droplets in the milk. It belongs the immunoglobulin superfamily. BTN1A1 acts as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane. It is localized to the major histocompatibility complex (MHC) class I region of 6p. It may have arisen relatively recently in evolution by the shuffling of exons between 2 ancestral gene families. It is shown that BTN1A1 inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion. |
| 蛋白种属 | Human |
| 表达系统 | Human Cells |
| 标签 | C-Fc |
| 蛋白表达区间 | Ala27-Arg242 |
| 蛋白编号 | Q13410 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 干粉 |
| 剂型描述 | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。 分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 50.8 KDa |
| SMILES Code | NONE |
| 别名 | 重组人BTN1A1蛋白(C-Fc, HEK293) ;Recombinant Human BTN1A1 (C-Fc, HEK293); Butyrophilin Subfamily 1 Member A1; BT; BTN1A1; BTN |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Sealed in dry, store in freezer, under -20°C |
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