货号:A2925440
同义名:
重组人BMPR1A蛋白(C-Fc-6His, HEK293)
/ Recombinant Human BMPR1A (C-Fc-6His, HEK293); Bone Morphogenetic Protein Receptor Type-1A
Recombinant Human BMPR1A (C-Fc-6His, HEK293) 是人源骨形态发生蛋白受体1A,在HEK293细胞中表达,带有C端Fc和6His标签。该蛋白属于TKL丝/苏氨酸蛋白激酶家族和TGFβ受体亚家族,是单次跨膜I型蛋白,高表达于骨骼肌,包含GS结构域和蛋白激酶结构域,参与成骨细胞外基质沉积及SMAD信号通路激活,缺陷与幼年性息肉综合征、考登病和遗传性混合息肉综合征2相关。


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| 描述 | Bone Morphogenetic Protein Receptor Type-1A (BMPR1A) belongs to the TKL Ser/Thr protein kinase family and TGFB receptor subfamily, including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. BMPR1A is a single-pass type I membrane protein and highly expressed in skeletal muscle. BMPR1A contains one GS domain and one protein protein kinase domain. BMPR1A is necessary for the extracellular matrix depostition by osteoblasts. BMPR1A can activate SMAD transcriptional regulators, binding with ligands. Defects in BMPR1A are a cause of juvenile polyposis syndrome, Cowden disease and hereditary mixed polyposis syndrome 2 (HMPS2). |
| 蛋白种属 | Human |
| 表达系统 | Human Cells |
| 标签 | C-Fc-6His |
| 蛋白表达区间 | Gln24-Arg152 |
| 蛋白编号 | P36894 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 干粉 |
| 剂型描述 | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。 分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 42.1 KDa |
| SMILES Code | NONE |
| 别名 | 重组人BMPR1A蛋白(C-Fc-6His, HEK293) ;Recombinant Human BMPR1A (C-Fc-6His, HEK293); Bone Morphogenetic Protein Receptor Type-1A; BMP Type-1A Receptor; BMPR-1A; Activin Receptor-Like Kinase 3; ALK-3; Serine/Threonine-Protein Kinase Receptor R5; SKR5; CD292; BMPR1A; ACVRLK3; ALK3 |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Sealed in dry, store in freezer, under -20°C |
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