Human BCMA (C-mFc, HEK293)/人BCMA蛋白(C-mFc, HEK293)
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货号：A2925360同义名：
重组人BCMA蛋白(C-mFc, HEK293)
/ Recombinant Human BCMA (C-mFc, HEK293); Tumor necrosis factor receptor superfamily member 17
Recombinant Human BCMA (C-mFc, HEK293)是人类B细胞成熟抗原（BCMA），在人源细胞中表达，带有C端mFc标签。该蛋白属于TNF受体超家族（TNFRSF17），与TACI高度同源，可结合TNF配体超家族成员APRIL和BAFF，参与调控B细胞发育、功能及存活，主要表达于免疫器官和成熟B细胞系，定位于高尔基体，对IgM产生及B细胞存活具有促进作用。
Human BCMA (C-mFc, HEK293)/人BCMA蛋白(C-mFc, HEK293) 化学结构 CAS号：N/A
Human BCMA (C-mFc, HEK293)/人BCMA蛋白(C-mFc, HEK293) 3D分子结构 CAS号：N/A
Human BCMA (C-mFc, HEK293)/人BCMA蛋白(C-mFc, HEK293) 质控信息
Human BCMA (C-mFc, HEK293)/人BCMA蛋白(C-mFc, HEK293) 生物活性
描述
B cell maturation antigen (BCMA) is a member of the TNF receptor superfamily. It has been designated TNFRSF17. Mouse BCMA is a 185 amino acid (aa) protein consisting of a 49 aa extracellular domain, a 23 aa transmembrane domain, and a 113 aa intracellular domain. BCMA is a type III membrane protein containing one extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of the TNF ligand superfamily. BCMA expression has been found in immune organs and mature B cell lines. Although some expression has been observed at the cell surface, BCMA appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells. This data suggests that BCMA may play an important role in B cell development,function and regulation.
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human BCMA (C-mFc, HEK293)/人BCMA蛋白(C-mFc, HEK293) 技术信息
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