Human BAFF (N-Fc, HEK293)/人BAFF蛋白(N-Fc, HEK293)
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货号：A2925326同义名：
重组人BAFF蛋白(N-Fc, HEK293)
/ Recombinant Human BAFF (N-Fc, HEK293); Tumor necrosis factor ligand superfamily member 13B
Recombinant Human BAFF (N-Fc, HEK293)是人类BAFF蛋白，在HEK293人源细胞中表达，带有N端Fc标签。该蛋白属于TNF家族，广泛表达于外周血白细胞、单核/巨噬细胞、脾脏、淋巴结、骨髓及免疫细胞中，可结合BAFF受体（如BAFFR、TACI、BCMA），在调控B细胞与T细胞功能、促进B细胞存活及调节体液免疫中起关键作用，适用于免疫研究及相关药物开发。
Human BAFF (N-Fc, HEK293)/人BAFF蛋白(N-Fc, HEK293) 化学结构 CAS号：N/A
Human BAFF (N-Fc, HEK293)/人BAFF蛋白(N-Fc, HEK293) 3D分子结构 CAS号：N/A
Human BAFF (N-Fc, HEK293)/人BAFF蛋白(N-Fc, HEK293) 质控信息
Human BAFF (N-Fc, HEK293)/人BAFF蛋白(N-Fc, HEK293) 生物活性
描述
TNFSF13B/TNFSF20 belongs to the tumor necrosis factor family. It abundantly is expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines. Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. Isoform 3 acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. Isoform 2 heteromultimerizes with isoform 1, probably limiting the amount of functional isoform 1 on the cell surface. Isoform 3 is unlikely form trimers or bind to BAFF receptors. Mature human BAFF consists of a 46 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 218 aa extracellular domain (ECD) with a stalk region and one TNF-like domain. Within aa 134-285 of the ECD, human BAFF shares 72% aa sequence identity with mouse BAFF.
Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 15% Trehalose, 4% Mannitol, 0.05% Tween 80, 10 mM Methionine, pH 8.5.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human BAFF (N-Fc, HEK293)/人BAFF蛋白(N-Fc, HEK293) 技术信息
CAS号
N/A
分子量
43.3 KDa
SMILES Code
NONE
别名
重组人BAFF蛋白(N-Fc, HEK293)
;Recombinant Human BAFF (N-Fc, HEK293); Tumor necrosis factor ligand superfamily member 13B; B lymphocyte stimulator; BLyS; B-cell-activating factor; BAFF; Dendritic cell-derived TNF-like molecule; TNF- and APOL-related leukocyte expressed ligand 1; TALL-1
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Human BAFF (N-Fc, HEK293)/人BAFF蛋白(N-Fc, HEK293)
|Human BAFF (N-Fc, HEK293)/人BAFF蛋白(N-Fc, HEK293)
| 重组人BAFF蛋白(N-Fc, HEK293)
| Recombinant Human BAFF (N-Fc, HEK293)
| Tumor necrosis factor ligand superfamily member 13B
| B lymphocyte stimulator
| BLyS
| B-cell-activating factor
| BAFF
| Dendritic cell-derived TNF-like molecule
| TNF- and APOL-related leukocyte expressed ligand 1
| TALL-1
| N/A
| Macrophage CD Proteins
| TNF Superfamily
| B Cell CD Proteins
| Human BAFF (N-Fc, HEK293)/人BAFF蛋白(N-Fc, HEK293) 纯度/质量文件
| Human BAFF (N-Fc, HEK293)/人BAFF蛋白(N-Fc, HEK293) 生物活性
| Human BAFF (N-Fc, HEK293)/人BAFF蛋白(N-Fc, HEK293) 技术信息
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