Human B7-1 (C-6His, HEK293)/人B7-1蛋白(C-6His, HEK293)
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货号：A2925026同义名：
重组人B7-1蛋白(C-6His, HEK293)
/ Recombinant Human B7-1 (C-6His, HEK293); CD80
Recombinant Human B7-1 (C-6His, HEK293)是人源B7-1蛋白，在HEK293细胞中表达，带有C端6×His标签。该蛋白又称CD80，是免疫球蛋白超家族成员，通过结合T细胞表面的CD28和CTLA-4参与T细胞活化，主要与CTLA-4结合。其结构包含两个胞外Ig样结构域（IgV和IgC）及一个胞内域，主要表达于抗原呈递细胞如活化的B细胞、巨噬细胞和树突状细胞表面。
Human B7-1 (C-6His, HEK293)/人B7-1蛋白(C-6His, HEK293) 化学结构 CAS号：N/A
Human B7-1 (C-6His, HEK293)/人B7-1蛋白(C-6His, HEK293) 3D分子结构 CAS号：N/A
Human B7-1 (C-6His, HEK293)/人B7-1蛋白(C-6His, HEK293) 质控信息
Human B7-1 (C-6His, HEK293)/人B7-1蛋白(C-6His, HEK293) 生物活性
描述
Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. It is the ligand for two different proteins on the T cell surface: CD28 and CTLA-4. Studies have shown that CTLA-4 binds mostly to CD80. The structure presents two extracellular domains: a membrane distal variable-like domain (IgV) and a membrane proximal Ig constant-like domain (IgC) along with an intracellular domain. Both IgV and IgC consist of anti-parallel beta sandwiches joined by a short linker region. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells.
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human B7-1 (C-6His, HEK293)/人B7-1蛋白(C-6His, HEK293) 技术信息
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