Human Azurocidin (C-6His)/人Azurocidin蛋白(HEK293, C-6His) 质控信息
Human Azurocidin (C-6His)/人Azurocidin蛋白(HEK293, C-6His) 生物活性
描述
Azurocidin is an Azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. The Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. Azurocidin is a member of the serine protease family that includes Cathepsin G, Neutrophil Elastase (NE), and Proteinase 3 (PR3), however, Azurocidin is not a serine proteinase since the active site serine and histidine residues are replaced. Human Azurocidin together with NE and PR3 are expressed coordinately and are packaged together into azurophil granules during neutrophil differentiation. Azurocidin has been identified as a modulator of endothelial permeability and an important multifunctional inflammatory mediator. Neutrophils arriving first at sites of inflammation release Azurocidin which acts in a paracrine fashion on endothelial cells causing the development of intercellular gaps and allowing leukocyte extravasation. Azurocidin thus be regarded as a reasonable therapeutic target for a variety of inflammatory disease conditions.
Lyophilized from a 0.2 μm filtered solution of 20mM HEPES, 150mM NaCl, pH 7.5.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human Azurocidin (C-6His)/人Azurocidin蛋白(HEK293, C-6His) 技术信息
CAS号
N/A
分子量
25.24 KDa
SMILES Code
NONE
别名
重组人Azurocidin蛋白(HEK293, C-6His)
;Recombinant Human Azurocidin (C-6His); Azurocidin; Cationic Antimicrobial Protein CAP37; Heparin-Binding Protein; HBP; AZU1
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Human Azurocidin (C-6His)/人Azurocidin蛋白(HEK293, C-6His)
|Human Azurocidin (C-6His)/人Azurocidin蛋白(HEK293, C-6His)
| 重组人Azurocidin蛋白(HEK293, C-6His)
| Recombinant Human Azurocidin (C-6His)
| Azurocidin
| Cationic Antimicrobial Protein CAP37
| Heparin-Binding Protein
| HBP
| AZU1
| N/A
| Other Target Proteins
| Human Azurocidin (C-6His)/人Azurocidin蛋白(HEK293, C-6His) 纯度/质量文件
| Human Azurocidin (C-6His)/人Azurocidin蛋白(HEK293, C-6His) 生物活性
| Human Azurocidin (C-6His)/人Azurocidin蛋白(HEK293, C-6His) 技术信息
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