Human Artemin (E.coli)/人Artemin蛋白(Tag free, E.coli)
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货号：A2925206同义名：
重组人Artemin蛋白(Tag free, E.coli)
/ Recombinant Human Artemin (E.coli); Artemin
Recombinant Human Artemin (E.coli) 是人源Artemin蛋白，在大肠杆菌中表达，为无标签形式。该蛋白属于GDNF家族配体，与TGF-β超家族远缘相关，成熟区为113个氨基酸组成的二聚体，具有三对链内二硫键及特征性半胱氨酸结结构，与鼠源ARTN高度同源，可作用于啮齿类细胞。其通过结合GFRα-3/RET或可能的GFRα-1/RET受体复合物，发挥促进感觉神经元存活、引导交感神经轴突生长及缓解神经损伤相关疼痛的作用。
Human Artemin (E.coli)/人Artemin蛋白(Tag free, E.coli) 化学结构 CAS号：N/A
Human Artemin (E.coli)/人Artemin蛋白(Tag free, E.coli) 3D分子结构 CAS号：N/A
Human Artemin (E.coli)/人Artemin蛋白(Tag free, E.coli) 质控信息
Human Artemin (E.coli)/人Artemin蛋白(Tag free, E.coli) 生物活性
描述
Human Artemin is a GDNF family ligand that is distantly related to the TGF-β superfamily of molecules. It is synthesized as a preproprotein, and contains a variable length pre-, or signal sequence, plus a 68 amino acid (aa) proregion and a 113 aa mature segment. Following synthesis and proteolytic processing, mature ARTN is secreted as a presumably glycosylated, 28 kDa disulfide-linked homodimer that contains three intrachain disulfide bonds and the typical TGF-β signature cysteine-knot motif. In the mature region, human ARTN is 89% and 88% aa identical to rat and mouse ARTN, respectively. Human ARTN is active on rodent cells. The receptor for ARTN has been identified as the ligand binding subunit GFRα-3 plus the signal transducing subunit, RET. The GFRα-1/RET receptor complex has also been suggested to be a ligand binding unit for ARTN. ARTN is known to be a chemoattractant for sympathetic neuron axons innervating the developing cardiovascular system. It also promotes sensory neuron survival and likely plays a role in the development of the peripheral nervous system. Finally, it has been reported to reverse neuropathic pain due to nerve injury, and to help resolve morphological changes associated with nerve damage.
Lyophilized from a 0.2 μm filtered solution of 20mM HEPES, 150mM NaCl, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human Artemin (E.coli)/人Artemin蛋白(Tag free, E.coli) 技术信息
CAS号
N/A
分子量
12.1 KDa
SMILES Code
NONE
别名
重组人Artemin蛋白(Tag free, E.coli)
;Recombinant Human Artemin (E.coli); Artemin; ARTN; Enovin; Neublastin; EVN
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Human Artemin (E.coli)/人Artemin蛋白(Tag free, E.coli)
|Human Artemin (E.coli)/人Artemin蛋白(Tag free, E.coli)
| 重组人Artemin蛋白(Tag free, E.coli)
| Recombinant Human Artemin (E.coli)
| Artemin
| ARTN
| Enovin
| Neublastin
| EVN
| N/A
| TGF-beta Superfamily
| Neurotrophic Factors
| Human Artemin (E.coli)/人Artemin蛋白(Tag free, E.coli) 纯度/质量文件
| Human Artemin (E.coli)/人Artemin蛋白(Tag free, E.coli) 生物活性
| Human Artemin (E.coli)/人Artemin蛋白(Tag free, E.coli) 技术信息
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