Human APRIL (N-Flag-His)/人APRIL蛋白(HEK293, N-Flag-His) 质控信息
Human APRIL (N-Flag-His)/人APRIL蛋白(HEK293, N-Flag-His) 生物活性
描述
APRIL (a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily. It is synthesized as a 32 kDa proprotein which is cleaved by furin in the Golgi to release the active 17 kDa soluble molecule. Secreted human APRIL, which consists almost entirely of a single TNF homology domain, shares 85% amino acid sequence identity with mouse and rat APRIL. Both APRIL and its close relative BAFF bind and signal through the TNF superfamily receptors TACI and BCMA, while BAFF additionally functions through BAFF R. APRIL binds to heparan sulfate proteoglycans (HSPGs) independently of its binding to TACI and BCMA. APRIL can form bioactive heterotrimers with BAFF, and these circulate in the serum of patients with rheumatic immune disorders. APRIL enhances the proliferation and survival of plasma cells and also promotes T cell-dependent humoral responses. APRIL levels are elevated in the serum during coronary artery disease, and it is also elevated in many cancers primarily due to expression by tumor-infiltratin neutrophils.
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 1M NaCl, pH8.3.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human APRIL (N-Flag-His)/人APRIL蛋白(HEK293, N-Flag-His) 技术信息
CAS号
N/A
分子量
50 KDa
SMILES Code
NONE
别名
重组人APRIL蛋白(HEK293, N-Flag-His)
;Recombinant Human APRIL (N-Flag-His); Tumor necrosis factor ligand superfamily member 13; A proliferation-inducing ligand; APRIL; TNF- and APOL-related leukocyte expressed ligand 2; TALL-2; TNF-related death ligand 1; TRDL-1; CD256; TNFSF13
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Human APRIL (N-Flag-His)/人APRIL蛋白(HEK293, N-Flag-His)
|Human APRIL (N-Flag-His)/人APRIL蛋白(HEK293, N-Flag-His)
| 重组人APRIL蛋白(HEK293, N-Flag-His)
| Recombinant Human APRIL (N-Flag-His)
| Tumor necrosis factor ligand superfamily member 13
| A proliferation-inducing ligand
| APRIL
| TNF- and APOL-related leukocyte expressed ligand 2
| TALL-2
| TNF-related death ligand 1
| TRDL-1
| CD256
| TNFSF13
| N/A
| TNF Superfamily
| Human APRIL (N-Flag-His)/人APRIL蛋白(HEK293, N-Flag-His) 纯度/质量文件
| Human APRIL (N-Flag-His)/人APRIL蛋白(HEK293, N-Flag-His) 生物活性
| Human APRIL (N-Flag-His)/人APRIL蛋白(HEK293, N-Flag-His) 技术信息
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