Human ANGPTL7 (C-10His, HEK293)/人ANGPTL7蛋白(C-10His, HEK293)
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货号：A2925302同义名：
重组人ANGPTL7蛋白(C-10His, HEK293)
/ Recombinant Human ANGPTL7 (C-10His, HEK293); Angiopoietin-related protein 7
Recombinant Human ANGPTL7 (C-10His, HEK293)是人类ANGPTL7蛋白，在HEK293人源细胞中表达，带有C端10×His标签。该蛋白是一种分泌型糖蛋白，结构与血管生成素类似，能形成同源三聚体和四聚体，主要在角膜基质、小梁网和巩膜中表达，并在青光眼房水中升高。其表达受糖皮质激素、TGF-β和TNF-α调控，具有调节胶原和蛋白聚糖沉积、抑制肿瘤血管生成等生物学功能。
Human ANGPTL7 (C-10His, HEK293)/人ANGPTL7蛋白(C-10His, HEK293) 化学结构 CAS号：N/A
Human ANGPTL7 (C-10His, HEK293)/人ANGPTL7蛋白(C-10His, HEK293) 3D分子结构 CAS号：N/A
Human ANGPTL7 (C-10His, HEK293)/人ANGPTL7蛋白(C-10His, HEK293) 质控信息
Human ANGPTL7 (C-10His, HEK293)/人ANGPTL7蛋白(C-10His, HEK293) 生物活性
描述
Angiopoietin-like 7 (ANGPTL7) is a secreted glycoprotein that is structurally related to the angiopoietins. Members of this protein family contain an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain. ANGPTL7 shares 89% aa sequence identity with mouse and rat ANGPTL7. It is secreted as a 45-50kDa monomer that forms disulfide-linked homotrimers and tetramers via the coiled coil domain. ANGPTL7 is expressed in the corneal stroma, trabecular meshwork, and sclera and is elevated in glaucoma aqueous humor. Its production is up-regulated in trabecular meshwork cells by glucocorticoids and TGF-β and in cartilage by TNF-α. Overexpression of ANGPTL7 in trabecular meshwork cells inhibits the production of collagen and proteoglycans. When overexpressed in tumor cells it promotes collagen and proteoglycan deposition but inhibits tumor xenograft progression and tumor angiogenesis.
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 6% Trehalose, 4% Mannitol, 100mM NaCl, 0.05% Tween 80, pH6.0.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human ANGPTL7 (C-10His, HEK293)/人ANGPTL7蛋白(C-10His, HEK293) 技术信息
CAS号
N/A
分子量
38.4 KDa
SMILES Code
NONE
别名
重组人ANGPTL7蛋白(C-10His, HEK293)
;Recombinant Human ANGPTL7 (C-10His, HEK293); Angiopoietin-related protein 7; Angiopoietin-like factor; Angiopoietin-like protein 7; Cornea-derived transcript 6 protein; ANGPTL7; CDT6
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Human ANGPTL7 (C-10His, HEK293)/人ANGPTL7蛋白(C-10His, HEK293)
|Human ANGPTL7 (C-10His, HEK293)/人ANGPTL7蛋白(C-10His, HEK293)
| 重组人ANGPTL7蛋白(C-10His, HEK293)
| Recombinant Human ANGPTL7 (C-10His, HEK293)
| Angiopoietin-related protein 7
| Angiopoietin-like factor
| Angiopoietin-like protein 7
| Cornea-derived transcript 6 protein
| ANGPTL7
| CDT6
| N/A
| Angiopoietins
| Human ANGPTL7 (C-10His, HEK293)/人ANGPTL7蛋白(C-10His, HEK293) 纯度/质量文件
| Human ANGPTL7 (C-10His, HEK293)/人ANGPTL7蛋白(C-10His, HEK293) 生物活性
| Human ANGPTL7 (C-10His, HEK293)/人ANGPTL7蛋白(C-10His, HEK293) 技术信息
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