Human ANGPTL3 (C-Fc, HEK293)/人ANGPTL3蛋白(C-Fc, HEK293)
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货号：A2925621同义名：
重组人ANGPTL3蛋白(C-Fc, HEK293)
/ Recombinant Human ANGPTL3 (C-Fc, HEK293); Angiopoietin-related protein 3
Recombinant Human ANGPTL3 (C-Fc, HEK293)是人类来源的重组蛋白，在HEK293人源细胞中表达，带有C-Fc标签。该蛋白为血管生成素样蛋白3，结构与血管生成素相关，包含N端卷曲螺旋结构域和C端纤维蛋白原样结构域，主要由肝脏分泌，可循环于血浆中。其能够抑制脂蛋白脂肪酶和内皮脂肪酶活性，进而升高血浆甘油三酯水平，参与脂质代谢调控。
Human ANGPTL3 (C-Fc, HEK293)/人ANGPTL3蛋白(C-Fc, HEK293) 化学结构 CAS号：N/A
Human ANGPTL3 (C-Fc, HEK293)/人ANGPTL3蛋白(C-Fc, HEK293) 3D分子结构 CAS号：N/A
Human ANGPTL3 (C-Fc, HEK293)/人ANGPTL3蛋白(C-Fc, HEK293) 质控信息
Human ANGPTL3 (C-Fc, HEK293)/人ANGPTL3蛋白(C-Fc, HEK293) 生物活性
描述
Angiopoietin-like 3 (ANGPTL3) is a secreted glycoprotein that is structurally related to the angiopoietins. Mature human ANGPTL3 contains an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain. ANGPTL3 is expressed in the liver from early in development through adulthood. Full length ANGPTL3 circulates in the plasma as do the proteolytically separated N-and C-terminal segments containing the coiled coil domain and fibrinogen-like domains,respectively. ANGPTL3 directly inhibits lipoprotein lipase (LPL) and endothelial lipase (EL), enzymes responsible for hydrolyzing circulating triglycerides and HDL phospholipids. ANGPTL3 promotes an increase in circulating triglyceride levels without altering VLDL or HDL secretion or uptake. ANGPTL3 expression in vivo is up-regulated by LXR agonists and down-regulated by insulin, leptin, and agonists of TRβ or PPARβ.
Lyophilized from a 0.2 μm filtered solution of PBS, 5% Trehalose, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human ANGPTL3 (C-Fc, HEK293)/人ANGPTL3蛋白(C-Fc, HEK293) 技术信息
CAS号
N/A
分子量
50.7 KDa
SMILES Code
NONE
别名
重组人ANGPTL3蛋白(C-Fc, HEK293)
;Recombinant Human ANGPTL3 (C-Fc, HEK293); Angiopoietin-related protein 3; ANGPTL3; Angiopoietin-5; ANG-5; Angiopoietin-like protein 3; ANGPT5
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Human ANGPTL3 (C-Fc, HEK293)/人ANGPTL3蛋白(C-Fc, HEK293)
|Human ANGPTL3 (C-Fc, HEK293)/人ANGPTL3蛋白(C-Fc, HEK293)
| 重组人ANGPTL3蛋白(C-Fc, HEK293)
| Recombinant Human ANGPTL3 (C-Fc, HEK293)
| Angiopoietin-related protein 3
| ANGPTL3
| Angiopoietin-5
| ANG-5
| Angiopoietin-like protein 3
| ANGPT5
| N/A
| Angiopoietins
| Human ANGPTL3 (C-Fc, HEK293)/人ANGPTL3蛋白(C-Fc, HEK293) 纯度/质量文件
| Human ANGPTL3 (C-Fc, HEK293)/人ANGPTL3蛋白(C-Fc, HEK293) 生物活性
| Human ANGPTL3 (C-Fc, HEK293)/人ANGPTL3蛋白(C-Fc, HEK293) 技术信息
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