货号:A2900874
同义名:
重组人4-1BBL蛋白(E.coli, C-6His)
/ Recombinant Human 4-1BBL (C-6His); Tumor necrosis factor ligand superfamily member 9
Recombinant Human 4-1BBL (C-6His) 是人源重组4-1BBL蛋白,在大肠杆菌中表达,带有C端6×His标签。该蛋白是肿瘤坏死因子配体超家族成员9,属于II型跨膜蛋白,由254个氨基酸组成,广泛表达于脑、胎盘、肺、骨骼肌和肾脏。具有激活T淋巴细胞、促进增殖、调控活化诱导的细胞死亡及T细胞与免疫细胞相互作用等功能,对CD8+ T细胞应答及肿瘤免疫有重要作用。


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| 描述 | Tumor necrosis factor ligand superfamily member 9(4-1BBL) is single-pass type II membrane protein which is a member of the the tumor necrosis factor family. 4-1BBL is a 254 amino acids cytokine that is expressed in brain, placenta, lung, skeletal muscle and kidney. TNFSF9 has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine may have a role in activation-induced cell death (AICD) and cognate interactions between T-cells and B-cells/macrophages. It has also been shown to be required for the optimal CD8 responses in CD8 T cells, and is thought to be involved in T cell-tumor cell interaction. |
| 蛋白种属 | Human |
| 表达系统 | E.coli |
| 标签 | C-6His |
| 蛋白表达区间 | Arg71-Glu254 |
| 蛋白编号 | P41273 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 干粉 |
| 剂型描述 | Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 7.4. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。 分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 20.6 KDa |
| SMILES Code | NONE |
| 别名 | 重组人4-1BBL蛋白(E.coli, C-6His) ;Recombinant Human 4-1BBL (C-6His); Tumor necrosis factor ligand superfamily member 9; 4-1BB ligand; 4-1BBL; TNFSF9 |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Sealed in dry, store in freezer, under -20°C |
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