Human 4-1BB (C-6His, HEK293)/人4-1BB蛋白(C-6His, HEK293)
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货号：A2925124同义名：
重组人4-1BB蛋白(C-6His, HEK293)
/ Recombinant Human 4-1BB (C-6His, HEK293); CD137
Recombinant Human 4-1BB (C-6His, HEK293)是人源蛋白，在HEK293人源细胞中表达，带有C端6×His标签。该蛋白为肿瘤坏死因子受体超家族成员9（TNFRSF9），又称CD137或4-1BB，是一种诱导性T细胞表面蛋白，参与促进T细胞和树突状细胞的存活，通过与配体CD137L（4-1BBL）结合，在免疫应答中发挥关键作用。
Human 4-1BB (C-6His, HEK293)/人4-1BB蛋白(C-6His, HEK293) 化学结构 CAS号：N/A
Human 4-1BB (C-6His, HEK293)/人4-1BB蛋白(C-6His, HEK293) 3D分子结构 CAS号：N/A
Human 4-1BB (C-6His, HEK293)/人4-1BB蛋白(C-6His, HEK293) 质控信息
Human 4-1BB (C-6His, HEK293)/人4-1BB蛋白(C-6His, HEK293) 生物活性
描述
Tumor necrosis factor receptor superfamily member 9(TNFRSF9), also known as CD137 and 4-1BB, is an inducible T cell surface protein belonging to the tumor necrosis factor receptor superfamily. It is a single-pass type I membrane protein which contains 4 TNFR-Cys repeats. The human and mouse proteins share 60% amino acid sequence identity. CD137 is expressed by mesenchymal cells, including endothelial cells, chondrocytes, and cells of the central nervous system. CD137 is also broadly expressed by cells of the human immune system, is broadly expressed by cells of the human immune system, including activated CD8+ and CD4+ T cells, activated natural killer (NK) cells, follicular dendritic cells (FDCs) and monocytes. CD137 has diverse roles in the immune response, the one key function is to promote the survival of both T cells and dendritic cells by binding the cognate ligand CD137L (4-1BBL).
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human 4-1BB (C-6His, HEK293)/人4-1BB蛋白(C-6His, HEK293) 技术信息
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