Hesperidin methylchalcone, an orally active flavonoid, possesses analgesic, anti-inflammatory, and antioxidant effects. It demonstrates vasoprotective activity and inhibits oxidative stress, cytokine production, and NF-κB activation. Hesperidin methylchalcone is applicable in gout disease research[1][2].
体内研究
Hesperidin methylchalcone (0.03-3 mg/kg, i.p., once time) dose-dependently reduces the increase of renal dysfunction markers (urea and creatinine) caused by SDCF in mice[1].
Hesperidin methylchalcone (3 mg/kg, i.p., once time) effectively mitigates oxidative stress induced by SDCF in the renal tissue of mice[1].
Hesperidin methylchalcone (3 mg/kg, i.p., single dose) alleviates SDCF-induced renal histopathology, swelling, and cytotoxicity in tubular cells of mice[1].
Hesperidin methylchalcone (3-30 mg/kg, p.o., single dose) dose-dependently diminishes MSU-induced hyperalgesia, edema, and leukocyte infiltration in mice[2].
Hesperidin methylchalcone 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Mice
TiO2-induced chronic arthritis model
Intraperitoneal injection
100 mg/kg
Once daily for 30 days
HMC inhibited mechanical hyperalgesia, thermal hyperalgesia, joint edema, leukocyte recruitment, and oxidative stress in the knee joint (alterations in gp91phox, GSH, superoxide anion, and lipid peroxidation) and in recruited leukocytes (total reactive oxygen species and GSH); reduced patellar proteoglycan degradation; and decreased pro-inflammatory cytokine production. HMC also reduced the activation of nociceptor-sensory TRPV1+ and TRPA1+ neurons. These effects occurred without renal, hepatic, or gastric damage.
Molecules. 2023 Jan 15;28(2):872
Swiss mice
Diclofenac-induced acute kidney injury
Intra-peritoneal injection
0.03–3 mg/kg
Single dose, evaluated after 24 hours
To evaluate the protective effects of HMC on diclofenac-induced acute kidney injury. Results showed that HMC dose-dependently improved renal function markers (urea and creatinine levels), reduced oxidative stress and inflammatory responses.
搜索
