MA inhibits Piezo1 currents by increasing the mechanical threshold required for activation.
Nat Commun. 2019 Mar 13;10(1):1200
mouse neuro-2a (N2A) cells
100 µM
18 hours
MA inhibits Piezo1 currents by increasing the mechanical threshold required for activation.
Nat Commun. 2019 Mar 13;10(1):1200
colonic circular muscle cells
50 and 100 μM
to investigate the effects of C17:0 and C18:0 on colonic muscle contraction, showing they dose-dependently enhanced contraction amplitudes
Microbiome. 2018 Jun 14;6(1):107
primary mouse hepatocytes
125 µM
24 or 48 hours
To evaluate the effects of heptadecanoic acid on lipid metabolism and inflammatory signaling in hepatocytes. Results showed that C17:0 treatment increased the expression of lipogenic genes but had no effect on insulin-stimulated AKT phosphorylation, while suppressing JAK2/STAT3 signaling.
Nutrients. 2023 Apr 24;15(9):2052
Heptadecanoic Acid/十七烷酸 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
C57BL/6JRj mice
High-fat diet-induced hepatic steatosis and insulin resistance model
Dietary supplementation
5%
For 20 weeks
To assess the effects of long-term heptadecanoic acid supplementation on high-fat diet-induced hepatic steatosis and insulin resistance. Results showed that C17:0 supplementation did not improve hepatic lipid accumulation or insulin resistance and had no significant effect on hepatic lipid metabolism.
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