HSF1A
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货号：A327751
HSF1A是热休克转录因子 1（HSF1）的激活剂。
HSF1A 化学结构
HSF1A 3D分子结构
规格
价格
会员价
库存
数量
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HSF1A 纯度/质量文件 产品仅供科研
货号：A327751
标准纯度：
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产品说明书
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HSF1A 质控信息
HSF1A 生物活性
描述
HSF1A is an activator of Heat shock transcription factor 1 (HSF1).
HSF1A 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Mouse embryonic fibroblasts (MEFs)
50 μM
HSF1A provided similar protection against TcdB as observed in HeLa cells
Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9580-9585
HeLa cells
50 μM
90 minutes
HSF1A blocked TcdB-induced cytotoxicity in a concentration-dependent manner, with 50 μM completely blocking it
Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9580-9585
Primary neonatal rat ventricular myocytes (NRVMs)
10 μM
24 hours
HSF1A significantly enhanced the ability of CHIP-ΔM/U to inhibit IGF-IIR expression, reduce caspase-3 activation and retained cell viability.
Cell Death Dis. 2016 Nov 3;7(11):e2455
H9c2 cells
10 μM
24 hours
HSF1A significantly inhibited DOX-induced IGF-IIR upregulation, caspase-3 cleavage and caspase-3 activity.
Cell Death Dis. 2016 Nov 3;7(11):e2455
A549 cells
200 µM
4 hours
To evaluate the protective effects of HSF1A against PT-induced cell intoxication in A549 cells. Results showed that HSF1A also effectively reduced PT intoxication in A549 cells.
Toxins (Basel). 2024 Jan 10;16(1):36
CHO cells
200 µM
4 hours
To evaluate the protective effects of HSF1A against PT-induced cell intoxication. Results showed that HSF1A effectively reduced the levels of ADP-ribosylated Gαi in PT-treated cells.
Toxins (Basel). 2024 Jan 10;16(1):36
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HSF1A 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Wistar Kyoto rats (WKY)
DOX-induced cardiomyopathy model
Intraperitoneal injection
100 mg/kg/day
Once daily for 6 weeks
HSF1A significantly alleviated DOX-induced cardiac dysfunction and minimized cardiac damage, reducing TUNEL-positive cardiomyocytes.
Cell Death Dis. 2016 Nov 3;7(11):e2455
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HSF1A 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.44mL
0.49mL
0.24mL
12.21mL
2.44mL
1.22mL
24.42mL
4.88mL
2.44mL
HSF1A 技术信息
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