L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
H-Arg-OH·HCl/L-精氨酸盐酸盐 细胞实验
Cell Line
Concentration
Treated Time
Description
References
AR42J cells
1 mM and 2.5 mM
3 to 12 hours
To investigate the effect of L-arginine on NCX1 protein expression. Results showed that 1 mM and 2.5 mM L-arginine treatment for 3 to 12 hours gradually increased NCX1 protein expression, with a more distinct trend in the 1 mM treatment group.
Pancreas. 2020 Jan;49(1):111-119.
Porcine alveolar macrophages (PAM)
2, 5, 10, 20, 40 mM
24 hours pretreatment, 72 hours post-infection
To study the effect of L-Arginine on ASFV replication, it was found that L-Arginine concentrations above 20 mM significantly promoted ASFV replication
Viruses. 2021 Jun 26;13(7):1236.
H-Arg-OH·HCl/L-精氨酸盐酸盐 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Sprague-Dawley rats
L-arginine-induced acute pancreatitis model
Intraperitoneal injection
2.5 g/kg
Twice, 1 hour apart
To investigate the expression changes of NCX1 and NF-κB in the L-arginine-induced acute pancreatitis model. Results showed that between 3 and 12 hours after L-arginine treatment, pancreatic tissue exhibited early to middle phases of acute inflammation, with gradual increases in NCX1 and NF-κB expression.
Pancreas. 2020 Jan;49(1):111-119.
C57BL/6 mice
L-Arginine-induced acute pancreatitis model
Intraperitoneal injection
4 g/kg body weight
Hourly injection, a total of two times
Induced acute pancreatitis, leading to pancreatic tissue necrosis and inflammatory cell infiltration
Nutrients. 2023 Oct 18;15(20):4427
Mice
UT-A1/3−/− mice
Intravenous injection
1 μg/g BW
Single injection
To evaluate the effect of L-NAME on renal blood flow in UT-A1/3?/? mice. Results showed that L-NAME caused a significant decrease in renal blood flow, with a greater percentage decrease in UT-A1/3?/? mice compared to wild-type mice.
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