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Gatifloxacin Sesquihydrate/加替沙星 倍半水合物
Gatifloxacin Sesquihydrate/加替沙星 倍半水合物
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货号：A152235
同义名：
AM-1155 sesquihydrate; BMS-206584 sesquihydrate
Gatifloxacin Sesquihydrate是第四代氟喹诺酮类抗生素，具有广谱抗菌活性，可抑制细菌 II 型拓扑异构酶，IC50=13.8 μg/ml (金黄色葡萄球菌拓扑异构酶 IV) 和抑制大肠杆菌 DNA 解旋酶 (IC50=0.109 μg/ml)。
Gatifloxacin Sesquihydrate/加替沙星 倍半水合物 化学结构
Gatifloxacin Sesquihydrate/加替沙星 倍半水合物 3D分子结构
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Gatifloxacin Sesquihydrate/加替沙星 倍半水合物 纯度/质量文件 产品仅供科研
货号：A152235
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Gatifloxacin Sesquihydrate/加替沙星 倍半水合物 质控信息
Gatifloxacin Sesquihydrate/加替沙星 倍半水合物 生物活性
描述
Gatifloxacin (Sesquihydrate) is an antibiotic of the fourth-generation fluoroquinolone family. Ophthalmic gatifloxacin 0.3% is at least as effective as ciprofloxacin at healing corneal ulcers infected with Pseudomonas aeruginosa when gatifloxacin is administered less frequently than ciprofloxacin[3] [4] [2]
Gatifloxacin Sesquihydrate/加替沙星 倍半水合物 参考文献
[1] Pantel A, Petrella S, et al. Extending the definition of the GyrB quinolone resistance-determining region in Mycobacterium tuberculosis DNA gyrase for assessing fluoroquinolone resistance in M. tuberculosis. Antimicrob Agents Chemother. 2012 Apr;56(4):1990-6.
[2] Khurana G, Arora S, Pawar PK. Ocular insert for sustained delivery of gatifloxacin sesquihydrate: Preparation and evaluations. Int J Pharm Investig. 2012;2(2):70–77
[3] Jensen H, Zerouala C, Carrier M, Short B. Comparison of ophthalmic gatifloxacin 0.3% and ciprofloxacin 0.3% in healing of corneal ulcers associated with Pseudomonas aeruginosa-induced ulcerative keratitis in rabbits. J Ocul Pharmacol Ther. 2005;21(1):36–43
[4] Fukuda H, Hori S, Hiramatsu K. Antibacterial activity of gatifloxacin (AM-1155, CG5501, BMS-206584), a newly developed fluoroquinolone, against sequentially acquired quinolone-resistant mutants and the norA transformant of Staphylococcus aureus. Antimicrob Agents Chemother. 1998;42(8):1917–1922
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Gatifloxacin Sesquihydrate/加替沙星 倍半水合物 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
1.24mL
0.25mL
0.12mL
6.21mL
1.24mL
0.62mL
12.42mL
2.48mL
1.24mL
Gatifloxacin Sesquihydrate/加替沙星 倍半水合物 技术信息
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