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Ganciclovir/更昔洛韦 {[allProObj[0].p_purity_real_show]}

货号：A200267 同义名： 更昔洛韦 / BW 759; 2'-Nor-2'-deoxyguanosine

Ganciclovir（BW 759）是一种核苷类似物，是口服活性抗病毒剂，对CMV（巨细胞病毒）有活性。更昔洛韦在体外也对疱疹病毒组的一些成员及其他一些DNA病毒有活性。更昔洛韦抑制人类疱疹病毒（HSV 1和2，CMV）和腺病毒1、2、4、6、8、10、19、22和28型的体外复制。更昔洛韦对猫疱疹病毒1型（FHV-1）的IC50为5.2 μM，并能扩散到脑内。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Ganciclovir/更昔洛韦 化学结构 CAS号：82410-32-0
Ganciclovir/更昔洛韦 化学结构
CAS号：82410-32-0
Ganciclovir/更昔洛韦 3D分子结构
CAS号：82410-32-0
Ganciclovir/更昔洛韦 化学结构 CAS号：82410-32-0
Ganciclovir/更昔洛韦 3D分子结构 CAS号：82410-32-0
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Ganciclovir/更昔洛韦 纯度/质量文件 产品仅供科研

货号：A200267 标准纯度： {[allProObj[0].p_purity_real_show]}
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全球学术期刊中引用的产品

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Ganciclovir/更昔洛韦 生物活性

描述 Ganciclovir, a guanosine nucleoside analogue, is a well established broad-spectrum antiviral agent that inhibits replication of viral DNA and is active against both HSV-1 and -2 and several other viruses. Ganciclovir ophthalmic gel 0.15% is a five-times-daily topical preparation that is indicated for the treatment of acute herpetic keratitis (dendritic ulcers). Ganciclovir ophthalmic gel 0.15% was generally well tolerated and was associated with a significantly lower incidence of visual disturbances than aciclovir ointment 3% in the phase III trial[3]. TFT (trifluorothymidine) and GCV (Ganciclovir) are synergistic against acyclovir-susceptible HSV-1 at concentrations significantly less toxic than if each antiviral were used as a sole agent[4]. GCV is used as an antiviral drug, and the thymidine kinase, HSV‑TK can phosphorylate GCV to GCV‑TP, a competitive inhibitor of DNA synthesis, instead of guanine‑5'‑triphosphate in the process of DNA synthesis. HSV‑TK/GCV (Herpes simplex virus type 1 thymidine kinase/ganciclovir) can significantly cause the death of retinoblastoma cell lines, HXO‑RB44 and Y79[5]. When HSV-Tk(+) T cells are added to T cell-depleted BM a consequently developing GVH can be controlled by GCV treatment with 60-70% of the animals surviving[6]. Moreover, long-circulating liposome-encapsulated GCV is a new approach to drug carriers to enhance the efficacy of suicide gene therapy[7].

Ganciclovir/更昔洛韦 细胞实验

Cell Line
Concentration Treated Time Description References
Crandall-Rees feline kidney cells 8.9 µM, 17.8 µM, 89 µM 48 hours To evaluate the in vitro efficacy of Ganciclovir against feline herpesvirus type 1 (FHV-1), results showed that Ganciclovir significantly reduced the number, area, and diameter of viral plaques at all tested concentrations, with the highest concentration (89 µM) causing a 100% reduction in viral plaque number. J Feline Med Surg. 2021 Apr;23(4):400-404.

Ganciclovir/更昔洛韦 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
Cats Healthy cats Topical ocular administration 0.15% Every 8 hours for 7 days To assess the safety and ocular tolerability of 0.15% Ganciclovir eye gel (GEG) in healthy cats, results showed that GEG was well tolerated over 7 days with no observed local or systemic toxicity. J Feline Med Surg. 2021 Apr;23(4):400-404.
Cats Experimental FHV-1 ocular infection model Topical ocular administration 0.15% 3 times daily for 14 days To evaluate the efficacy of Ganciclovir ophthalmic gel in cats with experimental FHV-1 ocular infection, results showed that Ganciclovir significantly reduced clinical ocular disease scores, corneal leukocyte infiltrates, and ocular viral loads. J Ocul Pharmacol Ther. 2022 Jun;38(5):339-347

Ganciclovir/更昔洛韦 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01663740 Cytomegalovirus Infections Phase 4 Completed - United States, California ... 展开 >> National Institute of Transplantation Los Angeles, California, United States, 90057 University of California Los Angeles (UCLA) Los Angeles, California, United States, 90095 University of California at San Francisco San Francisco, California, United States, 94115 United States, District of Columbia Washington Hospital Center Washington, District of Columbia, United States, 20010 United States, Georgia Medical College of Georgia Augusta, Georgia, United States, 30912 United States, Massachusetts Tufts Medical Center Boston, Massachusetts, United States, 02111 Western New England Renal & Transplant Associates, P.C. Springfield, Massachusetts, United States, 01107 United States, Minnesota University of Minnesota Minneapolis, Minnesota, United States, 55455 Mayo Clinic Rochester Rochester, Minnesota, United States, 55902 United States, New York Albany Medical Cancer Center Albany, New York, United States, 12208 University at Buffalo Buffalo, New York, United States, 14203 Stony Brook University Hospital Stony Brook, New York, United States, 11794 United States, Oregon Oregan Health & Science Univ Portland, Oregon, United States, 97237 United States, Pennsylvania Drexel University Department of Nephrology Philadelphia, Pennsylvania, United States, 19102 United States, Rhode Island Rhode Island Hospital Providence, Rhode Island, United States, 02903 United States, Texas Methodist Healthcare System of San Antonio San Antonio, Texas, United States, 78229 Mexico Hospital Miguel Hidalgo Aguascalientes, Mexico, 20230 Instituto Mexicano de Trasplantes Cuernavaca, Mexico, 62448 Hospital Central Dr. Ignacio Morones Prieto San Luis Potosi, Mexico, 78240 收起 <<
NCT00005025 Fallopian Tube Cancer ... 展开 >> Ovarian Cancer Primary Peritoneal Cavity Cancer 收起 << Phase 2 Unknown - United States, Iowa ... 展开 >> Human Gene Therapy Research Institute Des Moines, Iowa, United States, 50309 收起 <<
NCT02202564 Liver Cancer ... 展开 >>Hepatocellular Carcinoma 收起 << Phase 2 Completed - -

Ganciclovir/更昔洛韦 参考文献

[1]Tomicic MT, Thust R, Kaina B. Ganciclovir-induced apoptosis in HSV-1 thymidine kinase expressing cells: critical role of DNA breaks, Bcl-2 decline and caspase-9 activation. Oncogene. 2002 Mar 28;21(14):2141-53.

[2]Hamel W, Magnelli L, et al. Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells. Cancer Res. 1996 Jun 15;56(12):2697-702.

[3]Croxtall JD. Ganciclovir ophthalmic gel 0.15%: in acute herpetic keratitis (dendritic ulcers). Drugs. 2011 Mar 26;71(5):603-10

[4]Hobden JA, Kumar M, Kaufman HE, Clement C, Varnell ED, Bhattacharjee PS, Hill JM. In vitro synergism of trifluorothymidine and ganciclovir against HSV-1. Invest Ophthalmol Vis Sci. 2011 Feb 11;52(2):830-3

[5]Yi QY, Bai ZS, Cai B, Chen N, Chen LS, Yuan T, Mao JH. HSV‑TK/GCV can induce cytotoxicity of retinoblastoma cells through autophagy inhibition by activating MAPK/ERK. Oncol Rep. 2018 Aug;40(2):682-692

[6]Weijtens M, van Spronsen A, Hagenbeek A, de Weger R, Martens A. Ganciclovir-mediated elimination of HSV-Tk+ T cells and cure of graft-vs-host disease in an allogeneic bone marrow transplantation model in the rat. Exp Hematol. 2004 Oct;32(10):962-9

[7]Kajiwara E, Kawano K, Hattori Y, Fukushima M, Hayashi K, Maitani Y. Long-circulating liposome-encapsulated ganciclovir enhances the efficacy of HSV-TK suicide gene therapy. J Control Release. 2007 Jul 16;120(1-2):104-10

Ganciclovir/更昔洛韦 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.92mL

0.78mL

0.39mL

19.59mL

3.92mL

1.96mL

39.18mL

7.84mL

3.92mL

Ganciclovir/更昔洛韦 技术信息

CAS号82410-32-0
分子式C9H13N5O4
分子量 255.23
SMILES Code O=C1NC(N)=NC2=C1N=CN2COC(CO)CO
MDL No. MFCD00870588
别名 更昔洛韦 ;BW 759; 2'-Nor-2'-deoxyguanosine; 2'-Nor-2'-deoxyguanosine, BW 759, Ganciclovir; RS-21592
运输蓝冰
InChI Key IRSCQMHQWWYFCW-UHFFFAOYSA-N
Pubchem ID 135398740
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Keep in dark place, inert atmosphere, 2-8°C
溶解方案

DMSO: 60 mg/mL(235.08 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 1.5 mg/mL(5.88 mM)，配合低频超声助溶

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三
配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案 一

Tags: Ganciclovir | BW 759 | 更昔洛韦 | Antivirus | Nucleoside | HSV | AmBeed-信号通路专用抑制剂 | Ganciclovir/更昔洛韦 纯度/质量文件 | Ganciclovir/更昔洛韦 生物活性 | Ganciclovir/更昔洛韦 临床数据 | Ganciclovir/更昔洛韦 参考文献 | Ganciclovir/更昔洛韦 实验方案 | Ganciclovir/更昔洛韦 技术信息

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