Furazolidone (FZD) is a nitrofuran derivative with antiprotozoal and antibacterial activity, inhibits AML1-ETO (Acute myeloid leukemia ) transformed cells with IC50 value of 12.7 μM[3]. Biological in vitro evaluations demonstrated that free FZD and the FZD:β-CD complexes presented significant leishmanicidal activity against L. amazonensis with IC50 values of 6.16 μg/mL and 1.83 μg/mL for the complexes prepared by kneading and lyophilization, respectively[4]. Moreover, furazolidone was more effective and better tolerated than quinacrine for the treatment of giardiasis[5]. Furazolidone is known to induce a condition of cardiomyopathy in turkeys, which could be used as a model to study alpha 1-antitrypsin deficiency in man[6].
Furazolidone/呋喃唑酮 细胞实验
Cell Line
Concentration
Treated Time
Description
References
human hepatocyte L02 cells
10-60 µg/mL
24 hours
To evaluate the effect of FZD on L02 cell viability, results showed FZD reduced cell viability in a dose-dependent manner.
Molecules. 2016 Aug 22;21(8):1061
Helicobacter pylori
≥2 mg/l
72 hours
To evaluate the resistance of Furazolidone against Helicobacter pylori, the results showed a resistance rate of 0.28% (6/2109).
Front Cell Infect Microbiol. 2022 Sep 8;12:970630
Giardia lamblia WB C6
100 μM
Evaluate the inhibitory effect of furazolidone on Giardia lamblia, results showed that furazolidone was reduced by TrxR, increasing toxicity to the parasite.
Int J Parasitol Drugs Drug Resist. 2016 Dec;6(3):148-153
Pseudomonas bacteria (Pseudomonas sp. OS4, P. plecoglossicida IsA, Pseudomonas sp. MChB)
5 mg/L
24 hours
To assess the effect of furazolidone on bacterial metabolic activity, results showed that FZD combined with saponins significantly reduced bacterial metabolic activity, demonstrating a synergistic bactericidal effect.
World J Microbiol Biotechnol. 2023 Jun 5;39(8):221
Human colon epithelial cells CCD 841CoN
5 mg/L
48 hours
To evaluate the cytotoxicity of furazolidone combined with saponins, results showed an IC50 of 1.28 µg/mL for FZD, and the addition of saponins did not significantly alter its cytotoxicity.
World J Microbiol Biotechnol. 2023 Jun 5;39(8):221
Escherichia coli K12
2.5 μg/mL
24 hours
Evaluate the synergy between Furazolidone and Sodium Deoxycholate, showing FICI of 0.125, indicating synergistic inhibition
BMC Microbiol. 2020 Jan 6;20(1):5
peripheral blood mononuclear cells (PBMC)
>20 µM
72 hours
To evaluate the cytotoxicity of Furazolidone on PBMC, results showed no cytotoxic activity on the viability and proliferation of PBMC populations up to 20 µM.
Antimicrob Agents Chemother. 2018 Mar 27;62(4):e01834-17
Neonatal rat cardiomyocytes (NRCMs)
6.25–100 μM
48 hours
To evaluate the effects of furazolidone on cardiomyocyte viability and mitochondrial membrane potential, showing dose-dependent decreases in cell viability and MMP
PLoS One. 2013 Jun 20;8(6):e66779
Furazolidone/呋喃唑酮 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Sprague-Dawley rats
Furazolidone-induced dilated cardiomyopathy model
Gavage
0.3 mg/bodyweight (g)/day
Once daily for 8 weeks
Induced dilated cardiomyopathy model for subsequent stem cell and gene therapy studies
J Cell Mol Med. 2015 Aug;19(8):1868-76
Sprague-Dawley rats
Furazolidone-induced dilated cardiomyopathy model
Oral
700 ppm
Daily administration for thirty weeks
To establish a rat model of furazolidone-induced dilated cardiomyopathy, showing enlarged LV dimensions, reduced systolic and diastolic functions, myocardial fibrosis, and mitochondrial damage
Brazil
... 展开 >> Irmandade da Santa Casa de Misericordia se Sao Paulo
Sao Paulo, Brazil, 01221-020
Centro de Hematologia de Sao Paulo
Sao Paulo, Brazil, 01401-000
Federal University of Sao Paulo
Sao Paulo, Brazil, 04021-001
Hospital Estadual Infantil Darcy Vargas
Sao Paulo, Brazil, 05614-040 收起 <<
Duodenal Ulcer Due to Helicoba... 展开 >>cter Pylori 收起 <<
Phase 4
Recruiting
March 20, 2019
China, Hunan
... 展开 >> Hunan Provincial People's Hospital
Recruiting
Changsha, Hunan, China, 410002
Contact: JIANGTAO LIAO +8613574899399 jt99399@163.com
Changsha Central Hospital
Not yet recruiting
Changsha, Hunan, China, 410004
Contact: YA ZENG +8613637403676
The First Hospital of Changsha City
Not yet recruiting
Changsha, Hunan, China, 410005
Contact: LI LIU +8613975119635
Xiangya Hospital of Central South University
Not yet recruiting
Changsha, Hunan, China, 410008
Contact: MEIHUA XU +8613787270539 meihuaxu2001@yahoo.com.cn
The Second Xiangya Hospital of Central South University
Recruiting
Changsha, Hunan, China, 410011
Contact: CHUNLIAN WANG +8613973161116
The Third Xiangya Hospital of Central South University
Recruiting
Changsha, Hunan, China, 410013
Contact: CANXIA XU +8613786176248 xucanxia@163.com
The First Affiliated Hospital of University of South China
Not yet recruiting
Hengyang, Hunan, China, 421001
Contact: AIJUN LIAO +8613973400930 liaoaj163@163.com
Loudi central hospital
Recruiting
Loudi, Hunan, China, 417000
Contact: FENGQIAN SONG +8615873890651
Shaoyang Central Hospital
Recruiting
Shaoyang, Hunan, China, 422000
Contact: CHAOMIN LI +8613762857236
The Affiliated Hospital Of YongZhou Vocational Technical College
Recruiting
Yongzhou, Hunan, China, 425000
Contact: MING YANG +8613974621123 收起 <<
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