Fucoxanthin is a natural product isolated and purified from the herbs of Laminaria japonica with antiobesity and antioxidative effects.
Fucoxanthin/岩藻黄质 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Human dentin blocks
50 µg/mL, 100 µg/mL, 200 µg/mL
1 minute
To evaluate the inhibitory effect of Fucoxanthin on MMP activity, results showed decreased fluorescence intensity with increasing concentration, indicating MMP inhibition
Int J Nanomedicine. 2024 Dec 9;19:13253-13265
Human dentin slices
50 µg/mL, 100 µg/mL, 200 µg/mL
10 minutes
To evaluate the effect of Fucoxanthin on dentin collagen cross-linking, results showed increased collagen cross-linking with shifts in amide II bands in a concentration-dependent manner
Int J Nanomedicine. 2024 Dec 9;19:13253-13265
Caco-2 cells
0.1, 1, 10, 50 µg/mL
48 hours
Assessed metabolic activity and apoptotic activity, showing dose-dependent decrease in metabolic activity and increase in caspase 3/7 activity.
Antioxidants (Basel). 2019 Jun 19;8(6):183
HepG2 cells
0.1, 1, 10, 50 µg/mL
48 hours
Assessed metabolic activity and apoptotic activity, showing dose-dependent decrease in metabolic activity and increase in caspase 3/7 activity.
Antioxidants (Basel). 2019 Jun 19;8(6):183
HeLa cells
0.1, 1, 10, 50 µg/mL
24 hours
Assessed GSH/GSSG ratio, showing significant increase at 50 µg/mL.
Antioxidants (Basel). 2019 Jun 19;8(6):183
RAW 264.7 cells
0.1, 1, 10, 50 µg/mL
24 hours
Assessed metabolic activity, showing significant decrease in RAW 264.7 cells metabolic activity at 50 µg/mL.
Antioxidants (Basel). 2019 Jun 19;8(6):183
PBMCs
0.1, 1, 10, 50 µg/mL
24 hours
Assessed metabolic activity, showing no effect of Fucoxanthin on PBMCs metabolic activity up to 50 µg/mL.
Antioxidants (Basel). 2019 Jun 19;8(6):183
Retinal Müller cells (RMCs)
20 μg/mL
24 hours
To evaluate the photoprotective effect of Fucoxanthin on UVB-induced RMCs, results showed that Fucoxanthin significantly reduced UVB-induced oxidative damage and improved cell viability.
Food Chem X. 2024 Jul 14;23:101648
PC12 cells
0.1–5 µM
1 h pretreatment followed by 24 h exposure to Aβ25–35
Fucoxanthin inhibited Aβ25-35-induced cell death by recovering cell cycle arrest and decreasing intracellular reactive oxygen species (ROS) level.
Antioxidants (Basel). 2023 Mar 3;12(3):629
NIH/3T3 cells
20 μM
48 hours
Assess the effect of siTwist/FX@HES-CH on NIH/3T3 cells, showing inhibition of α-SMA expression.
J Adv Res. 2025 Apr;70:463-479
4T1 cells
20 μM
48 hours
Evaluate the cytotoxicity of siTwist/FX@HES-CH on 4T1 cells, showing significant synergistic anti-tumor effects.
J Adv Res. 2025 Apr;70:463-479
Fucoxanthin/岩藻黄质 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Sprague Dawley rats
PAMP LPS-induced uveitis
Gavage
0.1, 1, or 10 mg/kg BW
Once daily for 2 days
To investigate the anti-inflammatory effects of fucoxanthin on PAMP LPS-induced uveitis. The results showed that fucoxanthin significantly enhanced the expression of Nrf2, increased the activity of superoxide dismutase, and decreased the levels of malondialdehyde. It alleviated ocular hypertension, inflammatory cells, and proinflammatory cytokine TNF-α levels, preserved iris sphincter innervation and pupillary function, and inhibited corneal endothelial disruption.
Antioxidants (Basel). 2021 Jul 7;10(7):1092
BALB/c mice
4T1 orthotopic tumor model
Intravenous injection
15 mg/kg FX and 1 mg/kg siTwist
Every 3 days for a total of 6 times
Evaluate the inhibitory effect of siTwist/FX@HES-CH on TNBC orthotopic tumors, showing significant reduction in tumor burden and inhibition of lung metastasis.
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