There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Fluorometholone acetate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. Hourly topical administration of 0.1% fluorometholone acetate ophthalmic suspension produced, on the average, a 47% reduction in the polymorphonuclear leukocytes invading the cornea during an experimentally induced inflammatory keratitis[3]. Fluorometholone acetate potently inhibits carbonic anhydrase (CA) with IC50s of 2.18 μM and 17.5 μM for hCA-I and hCA-II, respectively. Fluorometholone acetate has anti-inflammatory effect and has the potential for external ocular inflammation research[4].
Fluorometholone acetate/氟米龙醋酸酯 细胞实验
Cell Line
Concentration
Treated Time
Description
References
UMRC6 cells
100 nM and 10 μM
24 hours
Validate the anti-tumor effects of Fluorometholone in another RCC cell line
PLoS One. 2015 Apr 2;10(4):e0122442
Caki-1 cells
100 nM and 10 μM
24 hours
Assess the dose-dependent enhancement of NaK-β1 expression by Fluorometholone
PLoS One. 2015 Apr 2;10(4):e0122442
HeLa cells
10 μM
24 hours
Validate the enhancement of NaK-β1 expression by Fluorometholone
PLoS One. 2015 Apr 2;10(4):e0122442
Fluorometholone acetate/氟米龙醋酸酯 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
SCID mice
Subcutaneous RCC xenograft model
Intraperitoneal injection
5 mg/kg body weight
Every other day for five weeks
Evaluate the inhibitory effects of Fluorometholone on RCC tumor growth and invasiveness
PLoS One. 2015 Apr 2;10(4):e0122442
BALB/c mice
Ocular alkali burn model
Topical eye drops
0.1% (1 mg/mL)
Twice daily for 1 week
To evaluate the therapeutic effects of fluorometholone in an ocular alkali burn model, results showed that fluorometholone significantly reduced corneal opacity and epithelial defects, decreased inflammatory cell infiltration and inflammatory cytokine expression
Sci Rep. 2021 Mar 25;11(1):6909
Porcine
Porcine corneal tissue
Eye drop
0.1% (w/v)
5 hours
To evaluate the permeation enhancing effect of polymeric micelles on fluorometholone in porcine corneal tissue. Results showed that polymeric micelles significantly increased the permeation and deposition of fluorometholone.
Terminated(Terminated to initi... 展开 >>ate FDA IND-cleared study protocol) 收起 <<
-
United States, California
... 展开 >>
Clear View Eye & Laser Medical Center
San Diego, California, United States, 92121
United States, Colorado
Corneal Consultants of Colorado, P.C
Littleton, Colorado, United States
United States, Illinois
Chicago Cornea Consultants, LTD
Hoffman Estates, Illinois, United States
United States, Minnesota
Minnesota Eye Consultants, P.A.
Bloomington, Minnesota, United States, 55431
United States, Texas
Cornea Associates of Texas
Dallas, Texas, United States, 75231 收起 <<
United States, California
... 展开 >>
Navy Warfighter Refractive Surgery Center
Recruiting
San Diego, California, United States, 92134
Contact: Donna Murdoch, Ph.D. 619-524-0771 donna.m.murdoch.ctr@mail.mil
Contact: Hong Gao, O.D., Ph.D. 619-524-0771 hong.gao1.mil@mail.mil
Principal Investigator: John B Cason, M.D. 收起 <<
Terminated(Terminated to initi... 展开 >>ate FDA IND-cleared study protocol) 收起 <<
-
United States, Florida
... 展开 >>
The Center for Excellence in Eye Care
Miami, Florida, United States, 33176
United States, Maryland
TLC Laser Eye Center
Rockville, Maryland, United States, 20852
United States, Virginia
TLC Laser Eye Center
Fairfax, Virginia, United States, 22031 收起 <<
United States, Massachusetts
... 展开 >>
Beth Israel Deaconess Medical Center
Recruiting
Boston, Massachusetts, United States, 02115
Contact: Juho Whang jwhang@bidmc.harvard.edu
Principal Investigator: Eric Wong, MD
Dana-Farber Cancer Institute
Recruiting
Boston, Massachusetts, United States, 02115
Contact: Elysia Larson ELARSON@LROC.HARVARD.EDU
Principal Investigator: Stephanie E Weiss, MD
United States, New York
Department of Radiation oncology, Memorial Sloan Kettering Cancer Center
Recruiting
New York city, New York, United States, 10065
Contact: Gina Giannantoni-ibelli GiannanG@mskcc.org
Principal Investigator: Kathryn Beal, MD
United States, Pennsylvania
UPMC Shadyside Radiation Oncology
Recruiting
Pittsburgh, Pennsylvania, United States, 15232
Contact: Rhonda Berlin berlinrL@upmc.edu
Principal Investigator: Heron Dwight, MD 收起 <<
Terminated(Terminated to initi... 展开 >>ate FDA IND-cleared study protocol) 收起 <<
-
United States, Arizona
... 展开 >>
Schwartz Laser Eye Center
Scottsdale, Arizona, United States, 85260
United States, California
Harvard Eye Associates
Laguna Hills, California, United States
Clear View Eye & Laser Medical Center
San Diego, California, United States
San Francisco, California, United States
Davidorf Eye Group
West Hills, California, United States
United States, Colorado
Corneal Consultants of Colorado, P.C
Littleton, Colorado, United States
United States, Florida
The Center for Excellence in Eye Care
Miami, Florida, United States, 33176
United States, Illinois
Chicago Cornea Consultants, LTD
Hoffman Estates, Illinois, United States, 60169
United States, Maryland
TLC Laser Eye Center
Rockville, Maryland, United States, 20852
United States, Massachusetts
Talamo Laser Eye Center
Waltham, Massachusetts, United States
United States, Missouri
Ophthalomology Associates
Saint Louis, Missouri, United States
United States, New York
South Shore Eye Care LLP
Wantagh, New York, United States, 11793
United States, Ohio
Cleveland Eye Clinic
Brecksville, Ohio, United States, 44141
United States, Virginia
TLC Laser Eye Center
Fairfax, Virginia, United States, 22031
United States, Washington
Northwest Eye Surgeons
Seattle, Washington, United States
Empire Eye Physicians
Spokane Valley, Washington, United States 收起 <<
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