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/ Famciclovir/泛昔洛韦

Famciclovir/泛昔洛韦 {[allProObj[0].p_purity_real_show]}

货号：A643497 同义名： 泛昔洛韦 / BRL 42810

Famciclovir是一种鸟苷类抗病毒药物，通过作为疱疹 simplex 2 型 DNA 聚合酶的竞争性抑制剂发挥作用。

Famciclovir/泛昔洛韦 化学结构 CAS号：104227-87-4
Famciclovir/泛昔洛韦 化学结构
CAS号：104227-87-4
Famciclovir/泛昔洛韦 3D分子结构
CAS号：104227-87-4
Famciclovir/泛昔洛韦 化学结构 CAS号：104227-87-4
Famciclovir/泛昔洛韦 3D分子结构 CAS号：104227-87-4
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Famciclovir/泛昔洛韦 纯度/质量文件 产品仅供科研

货号：A643497 标准纯度： {[allProObj[0].p_purity_real_show]}
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Famciclovir/泛昔洛韦 生物活性

描述 Famciclovir is the prodrug of penciclovir, a guanosine analogue that inhibits viruses of the alpha sub-family of the Herpesviridae, as well as hepatitis B virus. It is indicated for management of mucocutaneous herpes simplex virus disease and acute herpes zoster, and has been investigated for management of hepatitis B virus infection[3]. Famciclovir (Famvir) is the oral prodrug of penciclovir, an agent that has demonstrated antiviral activity against herpes simplex viruses, type 1 (HSV-1) and 2 (HSV-2) [which cause orolabial and/or genital herpes simplex], and against varicella zoster virus (VZV) [a reactivation of which leads to herpes zoster][4]. Famciclovir is an effective treatment of immunocompetent patients with acute herpes zoster (shingles) caused by VZV(varicella zoster virus). Famciclovir has therapeutic efficacy similar to that of oral aciclovir (acyclovir) in attenuating the acute signs and symptoms of infection (including pain during the acute phase of infection). In immunocompetent patients with recurrent genital herpes infection, suppressive treatment with oral famciclovir effectively prolonged the time to recurrence of symptomatic episodes of infection compared with placebo. In addition, famciclovir significantly reduced the duration of viral shedding, accelerated healing of genital herpes lesions and reduced the duration of symptoms[5].

Famciclovir/泛昔洛韦 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03120962 Herpes Zoster ... 展开 >> Post-herpetic Neuralgia 收起 << Not Applicable Not yet recruiting November 2020 -
NCT00477334 Genital Herpes Phase 4 Completed - -
NCT00219310 Recurrent Genital Herpes (RGH) Phase 4 Completed - United States, New Jersey ... 展开 >> Novartis Pharmaceuticals East Hanover, New Jersey, United States 收起 <<

Famciclovir/泛昔洛韦 参考文献

[1]Trepo C, Jezek P, et al. Famciclovir in chronic hepatitis B: results of a dose-finding study. J Hepatol. 2000 Jun;32(6):1011-8.

[2]Harrell AW, Wheeler SM, et al. Evidence that famciclovir (BRL 42810) and its associated metabolites do not inhibit the 6 beta-hydroxylation of testosterone in human liver microsomes. Drug Metab Dispos. 1993 Jan-Feb;21(1):18-23.

[3]Mubareka S, Leung V, Aoki FY, Vinh DC. Famciclovir: a focus on efficacy and safety. Expert Opin Drug Saf. 2010 Jul;9(4):643-58

[4]Simpson D, Lyseng-Williamson KA. Famciclovir: a review of its use in herpes zoster and genital and orolabial herpes. Drugs. 2006;66(18):2397-416

[5]Perry CM, Wagstaff AJ. Famciclovir. A review of its pharmacological properties and therapeutic efficacy in herpesvirus infections. Drugs. 1995 Aug;50(2):396-415

Famciclovir/泛昔洛韦 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.11mL

0.62mL

0.31mL

15.56mL

3.11mL

1.56mL

31.12mL

6.22mL

3.11mL

Famciclovir/泛昔洛韦 技术信息

CAS号104227-87-4
分子式C14H19N5O4
分子量 321.33
SMILES Code NC1=NC=C2N=CN(CCC(COC(C)=O)COC(C)=O)C2=N1
MDL No. MFCD00866964
别名 泛昔洛韦 ;BRL 42810
运输蓝冰
InChI Key GGXKWVWZWMLJEH-UHFFFAOYSA-N
Pubchem ID 3324
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place, inert atmosphere, 2-8°C
溶解方案

DMSO: 105 mg/mL(326.77 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(155.6 mM)，配合低频超声助溶

Tags: Famciclovir | 104227-87-4 | BRL 42810 | BRL42810 | BRL-42810 | Anti-infection | HSV | HBV | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Famciclovir/泛昔洛韦 纯度/质量文件 | Famciclovir/泛昔洛韦 生物活性 | Famciclovir/泛昔洛韦 临床数据 | Famciclovir/泛昔洛韦 参考文献 | Famciclovir/泛昔洛韦 实验方案 | Famciclovir/泛昔洛韦 技术信息

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