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首页 / Eicosapentaenoic acid ethyl ester/二十碳五烯酸乙酯

Eicosapentaenoic acid ethyl ester/二十碳五烯酸乙酯 {[allProObj[0].p_purity_real_show]}

货号：A759947 同义名： 顺-二十碳五烯酸乙酯 / EPA ethyl ester; Ethyl eicosapentaenoate

Eicosapentaenoic acid ethyl ester is an omega-3 fatty acid agent.

Eicosapentaenoic acid ethyl ester/二十碳五烯酸乙酯 化学结构 CAS号：86227-47-6
Eicosapentaenoic acid ethyl ester/二十碳五烯酸乙酯 化学结构
CAS号：86227-47-6
Eicosapentaenoic acid ethyl ester/二十碳五烯酸乙酯 3D分子结构
CAS号：86227-47-6
Eicosapentaenoic acid ethyl ester/二十碳五烯酸乙酯 化学结构 CAS号：86227-47-6
Eicosapentaenoic acid ethyl ester/二十碳五烯酸乙酯 3D分子结构 CAS号：86227-47-6
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Eicosapentaenoic acid ethyl ester/二十碳五烯酸乙酯 纯度/质量文件 产品仅供科研

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Eicosapentaenoic acid ethyl ester/二十碳五烯酸乙酯 生物活性

描述 Eicosapentaenoic acid ethyl ester is an omega-3 fatty acid agent. The enhanced contractile response by phenylephrine in diabetic mice was not altered by the administration of EPA-E (10 mg/day). In addition, the direct administration of EPA-E metabolites such as EPA, docosahexaenoic acid, and docosapentaenoic acid led to vasodilation in the aortic rings of C57BL/6 J mice. Chronic EPA-E administration prevented the development of endothelial dysfunction in KKAy mice, partly via the direct action of EPA-E metabolites on the aorta[3]. Oral administration of EPA-E ameliorated skin barrier dysfunction and pruritus in AD mice. In the SC of AD mice, covalently bound Cer were markedly diminished[4].

Eicosapentaenoic acid ethyl ester/二十碳五烯酸乙酯 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01002118 Cardiovascular Disease Not Applicable Terminated(Unable to recruit e... 展开 >>ligible subjects; no data analyzed) 收起 << - United States, Iowa ... 展开 >> University of Iowa Iowa City, Iowa, United States, 52242 收起 <<
NCT00504309 Hypertriglyceridemia Not Applicable Completed - United States, Pennsylvania ... 展开 >> Penn State University General Clinical Research Center University Park, Pennsylvania, United States, 16802 收起 <<
NCT01056133 Non-alcoholic Fatty Liver Dise... 展开 >>ase Non-alcoholic Steatohepatitis 收起 << Phase 2 Completed - Canada, Ontario ... 展开 >> University Health Network, Toronto General Hospital Toronto, Ontario, Canada, M5G 1Z5 收起 <<

Eicosapentaenoic acid ethyl ester/二十碳五烯酸乙酯 参考文献

[1]Jacobson TA. A new pure ω-3 eicosapentaenoic acid ethyl ester (AMR101) for the management of hypertriglyceridemia: the MARINE trial. Expert Rev Cardiovasc Ther. 2012 Jun;10(6):687-95.

[2]Bays HE, Ballantyne CM, et al. Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high triglyceride levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] trial). Am J Cardiol. 2011 Sep 1;108(5):682-90.

[3]Takenouchi Y, Ohtake K, Nobe K, Kasono K. Eicosapentaenoic acid ethyl ester improves endothelial dysfunction in type 2 diabetic mice. Lipids Health Dis. 2018 May 22;17(1):118

[4]Fujii M, Ohyanagi C, Kawaguchi N, Matsuda H, Miyamoto Y, Ohya S, Nabe T. Eicosapentaenoic acid ethyl ester ameliorates atopic dermatitis-like symptoms in special diet-fed hairless mice, partly by restoring covalently bound ceramides in the stratum corneum. Exp Dermatol. 2018 Aug;27(8):837-840

Eicosapentaenoic acid ethyl ester/二十碳五烯酸乙酯 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.03mL

0.61mL

0.30mL

15.13mL

3.03mL

1.51mL

30.26mL

6.05mL

3.03mL

Eicosapentaenoic acid ethyl ester/二十碳五烯酸乙酯 技术信息

CAS号86227-47-6
分子式C22H34O2
分子量 330.5
SMILES Code O=C(OCC)CCC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CC
MDL No. MFCD00673476
别名 顺-二十碳五烯酸乙酯 ;EPA ethyl ester; Ethyl eicosapentaenoate; Icosapent ethyl; AMR101
运输蓝冰
InChI Key SSQPWTVBQMWLSZ-AAQCHOMXSA-N
Pubchem ID 9831415
存储条件

In solvent -20°C:3-6个月-80°C:12个月
溶解方案

DMSO: 105 mg/mL(317.7 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 50 mg/mL(151.28 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二

Tags: Eicosapentaenoic acid ethyl ester | EPA ethyl ester;Ethyl eicosapentaenoate;Icosapent ethyl;AMR101 | 顺-二十碳五烯酸乙酯 | AmBeed-信号通路专用抑制剂 | Eicosapentaenoic acid ethyl ester/二十碳五烯酸乙酯 纯度/质量文件 | Eicosapentaenoic acid ethyl ester/二十碳五烯酸乙酯 生物活性 | Eicosapentaenoic acid ethyl ester/二十碳五烯酸乙酯 临床数据 | Eicosapentaenoic acid ethyl ester/二十碳五烯酸乙酯 参考文献 | Eicosapentaenoic acid ethyl ester/二十碳五烯酸乙酯 实验方案 | Eicosapentaenoic acid ethyl ester/二十碳五烯酸乙酯 技术信息

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