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/ VD/VDR / Doxercalciferol/度骨化醇

Doxercalciferol/度骨化醇 {[allProObj[0].p_purity_real_show]}

货号：A580119 同义名： 1.alpha.-Hydroxyvitamin D2; 1-hydroxy Vitamin D2

Doxercalciferol 是一种合成的维生素 D2 类似物，可抑制甲状旁腺激素的合成与分泌，适用于继发性甲状旁腺功能亢进及代谢性骨病的研究。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Doxercalciferol/度骨化醇 化学结构 CAS号：54573-75-0
Doxercalciferol/度骨化醇 化学结构
CAS号：54573-75-0
Doxercalciferol/度骨化醇 3D分子结构
CAS号：54573-75-0
Doxercalciferol/度骨化醇 化学结构 CAS号：54573-75-0
Doxercalciferol/度骨化醇 3D分子结构 CAS号：54573-75-0
规格 价格 会员价 库存 数量
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Doxercalciferol/度骨化醇 纯度/质量文件 产品仅供科研

货号：A580119 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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Doxercalciferol/度骨化醇 生物活性

描述 Doxercalciferol (DOX) is a Vitamin D2 analog, acts as an activator of Vitamin D receptor, and prevent renal disease. DOX had a beneficial effect on age-related bone deteriorations in aging mice by promoting osteoblast activity and cartilage regeneration and inhibiting osteoclast-specific genes expression[3]. Doxercalciferol (0.083, 0.167 or 0.333 μg/kg, i.p.) elevates serum phosphorus at Week 6 in 5/6 nephrectomized (NX) rats. Doxercalciferol (0.167 and 0.333 μg/kg) also increases serum calcium and Ca × P at Weeks 2 and 6, and enhances increased pulse wave velocity (PWV) at Week 6 in 5/6 nephrectomized (NX) rats. Doxercalciferol blocks PTH from rising at 0.083 μg/kg, and lowers serum PTH to the SHAM level[4]. Doxercalciferol was administered intraperitoneally at 150 ng, 3 times per week (Monday, Wednesday, Friday) for 6 weeks. Rats on HS diet with doxercalciferol administration had significant decrease in cardiac hypertrophy and improved cardiac function compared to the HS + vehicle. In addition, there was a significant decrease in plasma brain natriuretic peptide (BNP) level and tissue atrial natriuretic factor (ANF) mRNA level with doxercalciferol treatment. Doxercalciferol also significantly reduced the level of protein kinase C-α (PKCα)[5]. Doxercalciferol (125 ng/kg, i.p. thrice per week) increases expression of VDR mRNA level and renal expression of TRPV5 in NON mice fed a HF diet. Doxercalciferol also improves proteinuria, prevents loss of podocytes, and accumulation of extracellular matrix proteins in HF diet-induced mice[6].

Doxercalciferol/度骨化醇 细胞实验

Cell Line
Concentration Treated Time Description References
Huh7 cells 1.98 ± 1.30 μmol/L (EC50) 6 days To evaluate the inhibitory effect of Doxercalciferol on SFTSV-induced cytopathic effect (CPE), results showed dose-dependent protection against CPE. Virol Sin. 2024 Oct;39(5):802-811.
N2a wt cells 100 nM 18 hours Doxercalciferol significantly increased Aβ degradation to 158.2%. Int J Mol Sci. 2017 Dec 19;18(12):2764.
SH-SY5Y wt cells 100 nM 24 hours Doxercalciferol significantly reduced β-secretase activity to 77.3%. Int J Mol Sci. 2017 Dec 19;18(12):2764.
SH-SY5Y APP695 overexpressing cells 100 nM 24 hours Doxercalciferol significantly reduced total Aβ level to 70.9%. Int J Mol Sci. 2017 Dec 19;18(12):2764.

Doxercalciferol/度骨化醇 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
ICR suckling mice Lethal SFTSV infection model Intraperitoneal injection 0.3 or 0.15 μg/kg Daily for 8 days To evaluate the therapeutic effect of Doxercalciferol on SFTSV-infected ICR suckling mice, results showed increased survival rates (40% protection). Virol Sin. 2024 Oct;39(5):802-811.
LHβ-Tag transgenic mice Transgenic retinoblastoma model Oral gavage 0.1, 0.3, 0.5, or 1.0 µg/day Five times per week for 5 weeks To determine the effectiveness of 1α-OH-D2 in inhibiting retinoblastoma and evaluate its toxicity. Results showed significantly smaller tumor areas in all treatment groups compared to controls (P <.02), but no dose-dependent response curve. Higher mortality was observed in the 0.5 and 1.0 μg groups (P <.01). Trans Am Ophthalmol Soc. 2002;100:125-9

Doxercalciferol/度骨化醇 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01717989 - Completed - -
NCT01717989 - Completed - -
NCT01181531 - Completed - -

Doxercalciferol/度骨化醇 参考文献

[1]St-Arnaud R, Arabian A, et al. Differential effects of oral doxercalciferol (Hectorol) or paricalcitol (Zemplar) in the Cyp27b1-null mouse model of uremia. Nephron Exp Nephrol. 2011;119(3):e67-74.

[2]Choi JH, Ke Q, et al. Doxercalciferol, a pro-hormone of vitamin D, prevents the development of cardiac hypertrophy in rats. J Card Fail. 2011 Dec;17(12):1051-8.

[3]Li J, Li N, Yan S, Liu M, Sun B, Lu Y, Shao Y. Doxercalciferol Alleviates Bone Deteriorations and Cartilage Degeneration in Aging Mice. Exp Clin Endocrinol Diabetes. 2020 Aug;128(8):540-547

[4]Noonan W, Koch K, Nakane M, Ma J, Dixon D, Bolin A, Reinhart G. Differential effects of vitamin D receptor activators on aortic calcification and pulse wave velocity in uraemic rats. Nephrol Dial Transplant. 2008 Dec;23(12):3824-30

[5]Choi JH, Ke Q, Bae S, Lee JY, Kim YJ, Kim UK, Arbeeny C, Thadhani R, Kang PM. Doxercalciferol, a pro-hormone of vitamin D, prevents the development of cardiac hypertrophy in rats. J Card Fail. 2011 Dec;17(12):1051-8

[6]Wang XX, Jiang T, Shen Y, Santamaria H, Solis N, Arbeeny C, Levi M. Vitamin D receptor agonist doxercalciferol modulates dietary fat-induced renal disease and renal lipid metabolism. Am J Physiol Renal Physiol. 2011 Mar;300(3):F801-10

Doxercalciferol/度骨化醇 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.42mL

0.48mL

0.24mL

12.12mL

2.42mL

1.21mL

24.23mL

4.85mL

2.42mL

Doxercalciferol/度骨化醇 技术信息

CAS号54573-75-0
分子式C28H44O2
分子量 412.65
SMILES Code C=C1[C@H](C[C@@H](C/C1=C/C=C2[C@]3([C@@](C)([C@H](CC3)[C@@H](/C=C/[C@@H](C(C)C)C)C)CCC/2)[H])O)O
MDL No. MFCD00871065
别名 1.alpha.-Hydroxyvitamin D2; 1-hydroxy Vitamin D2; Doxercalciferol. 1-hydroxy Vitamin D2; TSA 840; 1-Hydroxyergocalciferol; Hectorol; 1α-hydroxyvitamin D2
运输蓝冰
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry, store in freezer, under -20°C
溶解方案

DMSO: 105 mg/mL(254.45 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二

Tags: Doxercalciferol | 54573-75-0 | 1.alpha.-Hydroxyvitamin D2 | VD/VDR | VD/VDR Activator | Vitamin D Related/Nuclear Receptor | VD/VDR | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Doxercalciferol/度骨化醇 纯度/质量文件 | Doxercalciferol/度骨化醇 生物活性 | Doxercalciferol/度骨化醇 临床数据 | Doxercalciferol/度骨化醇 参考文献 | Doxercalciferol/度骨化醇 实验方案 | Doxercalciferol/度骨化醇 技术信息

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