Diflorasone act as a corticosteroid hormone receptor agonist with anti-inflammatory and immunosuppressive properties. Diflorasone enters the cell by diffusion across the cell membrane and binds to the glucocorticoid receptor (GR) in the cytoplasm[1]. 0.05% diflorasone diacetate cream was as effective as 0.05% fluocinonide cream in the therapy of lesions of psoriasis or atopic/neurodermatitis[2]. Diflorasone inhibits RANTES and thymus and activation regulated chemokine (TARC) in a dinitrochlorobenzene-induced mouse model of allergic contact dermatitis[3]. It also inhibits proliferation of human keratinocytes in vitro and reduces epidermal thickening in a mouse model of psoriasis induced by imiquimod[4].
Diflorasone/二氟拉松 细胞实验
Cell Line
Concentration
Treated Time
Description
References
human peripheral blood T cells
1 µM
6 h
To evaluate the effect of Diflorasone on cytokine production, results showed that Diflorasone significantly inhibited the release of IL-2 and other cytokines.
Cell Commun Signal. 2025 Jun 4;23(1):268
human peripheral blood T cells
1 µM
2 h
To evaluate the effect of Diflorasone on TCR signaling, results showed that Diflorasone did not affect early TCR signaling.
Cell Commun Signal. 2025 Jun 4;23(1):268
human peripheral blood T cells
1 µM
2 h
To evaluate the effect of Diflorasone on T cell proliferation, results showed that Diflorasone significantly inhibited T cell proliferation.
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