HazMat Fee + There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
| Type | HazMat fee for 500 gram (Estimated) |
| Excepted Quantity | USD 0.00 |
| Limited Quantity | USD 15-60 |
| Inaccessible (Haz class 6.1), Domestic | USD 80+ |
| Inaccessible (Haz class 6.1), International | USD 150+ |
| Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
| Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |


| 规格 | 价格 | 会员价 | 库存 | 数量 | |||
|---|---|---|---|---|---|---|---|
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快速发货 顺丰冷链运输,1-2 天到达
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| 描述 | Diethylstilbestrol is a synthetic estrogen receptor agonist structurally related to estradiol. Diethylstilbestrol at 20µM results in 30±13% and 43±4% displacement of [3H]-estradiol from the sex hormone-binding globulin steroid-binding site in the serum and dextran-coated charcoal-treated serum[3]. Prostate cancer PC-3 cells treated with 30µM diethylstilbestrol for 72 hours show smaller nuclei compared with the control group. Diethylstilbestrol at 15 and 30µM induces apoptosis of androgen-insensitive prostate cancer cells[4]. |
| Concentration | Treated Time | Description | References | |
| Human umbilical vein endothelial cells (HUVECs) | 25-100 μM | DES significantly reduced HUVECs viability, inhibited VEGF-mediated wound closure and migration, and diminished capillary-like tube formation. | Clin Transl Med. 2020 Jun;10(2):e47. | |
| embryonic thymocytes | 25 μM | 18-24 h | To investigate the effects of DES on embryonic thymocyte death and differentiation, results showed DES induced cell death. | Int J Mol Sci. 2021 Sep 20;22(18):10138. |
| embryonic thymocytes | 50 μM | 18-24 h | To investigate the effects of DES on embryonic thymocyte death and differentiation, results showed DES induced cell death. | Int J Mol Sci. 2021 Sep 20;22(18):10138. |
| chicken oviductal epithelial cells (cOECs) | 100 μM | 1 week | Upregulated oviduct-specific genes (OVA, OVM, LYZ, AVD, ESR1) and enhanced secretion of EGFP and OVA proteins | Poult Sci. 2024 Jun;103(6):103723. |
| Administration | Dosage | Frequency | Description | References | ||
| Zebrafish | Juvenile zebrafish | Water exposure | 100 and 1000 ng/L | From 10 to 90 dpf, exposed in three stages (initial development stage (IDS, 10-25 dpf), gonadal differentiation stage (GDS, 25-45 dpf), and gonadal maturity stage (GMS, 45-60 dpf)) | To investigate the effects of DES on zebrafish gonad development and endocrine disruption mechanism at different developmental stages. Results showed that DES exposure during the gonadal differentiation stage (GDS) significantly reduced growth indicators (body length,, etc.) and significantly increased the proportion of females (59.65%), indicating a bias towards female differentiation. | Biomolecules. 2021 Jun 25;11(7):941 |
| Mice | Male mouse model | Oral | 0.2 µg/kg | Once daily from GD 11 to 17 and from PND 1 to 15 | To investigate the effects of perinatal DES exposure on the adult male urogenital tract, results showed DES exposure led to enlarged prostates, enlarged bladders, and urethral obstruction. | Int J Mol Sci. 2020 May 30;21(11):3902 |
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00428948 | Polycystic Kidney Disease, Aut... 展开 >>osomal Dominant 收起 << | Phase 3 | Completed | - | - |
| NCT00428948 | - | Completed | - | - | |
| NCT01212991 | Prostate Cancer | Phase 3 | Active, not recruiting | December 28, 2018 | - |
| 计算器 | ||||
| 存储液制备 | ![]() |
1mg | 5mg | 10mg |
|
1 mM 5 mM 10 mM |
3.73mL 0.75mL 0.37mL |
18.63mL 3.73mL 1.86mL |
37.26mL 7.45mL 3.73mL |
|
| CAS号 | 56-53-1 |
| 分子式 | C18H20O2 |
| 分子量 | 268.35 |
| SMILES Code | OC1=CC=C(C=C1)/C(CC)=C(CC)/C2=CC=C(O)C=C2 |
| MDL No. | MFCD00002373 |
| 别名 | Stilbestrol |
| 运输 | 蓝冰 |
| InChI Key | RGLYKWWBQGJZGM-ISLYRVAYSA-N |
| Pubchem ID | 448537 |
| 存储条件 |
In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Sealed in dry, room temperature |
| 溶解方案 |
DMSO: 50 mg/mL(186.32 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO 以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
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