Daucosterol is a natural sterolin isolated and purified from the herbs of Dioscorea nipponica Makino, has proliferation-enhancing activity and efficient and inexpensive neuroprotectant effect.
Daucosterol/胡萝卜苷 细胞实验
Cell Line
Concentration
Treated Time
Description
References
BHY (human oral squamous carcinoma)
74.14 μM
72 hours
Evaluate the anti-proliferative activity of Daucosterol on BHY cells, showing concentration-dependent inhibition.
Cell Prolif. 2014 Apr;47(2):172-9.
MCF-7 (human breast adenocarcinoma)
36.45 μM
72 hours
Evaluate the anti-proliferative activity of Daucosterol on MCF-7 cells, showing concentration-dependent inhibition.
Cell Prolif. 2014 Apr;47(2):172-9.
MC3T3-E1 cells
50, 100, 200 µg/mL
24 hours
Assessed cytotoxicity of Daucosterol on MC3T3-E1 cells, showing no significant toxicity.
Int J Mol Sci. 2023 Nov 17;24(22):16465.
RANKL-induced osteoclasts
50, 100, 200 µg/mL
5 days
Evaluated inhibitory effect of Daucosterol on osteoclast differentiation, showing significant suppression of TRAP activity and F-actin ring formation.
Int J Mol Sci. 2023 Nov 17;24(22):16465.
RAW 264.7 cells
50, 100, 200 µg/mL
24 hours
Assessed cytotoxicity of Daucosterol on RAW 264.7 cells, showing no significant toxicity.
Int J Mol Sci. 2023 Nov 17;24(22):16465.
HepG2 cells
500 nM
DAU alleviates alcohol-induced expression of lipid synthesis genes in HepG2 cells and reduces oxidative stress and inflammatory responses.
Nutrients. 2023 Jan 1;15(1):223.
Daucosterol/胡萝卜苷 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
ICR CD-1 mice
LPS-induced osteoporosis model
Intraperitoneal
20 mg/kg
For 9 consecutive days
Evaluated protective effect of Daucosterol against LPS-induced osteoporosis, showing significant inhibition of bone density loss and microarchitectural deterioration.
Int J Mol Sci. 2023 Nov 17;24(22):16465.
C57BL/6J male mice
Alcoholic liver disease model
Intragastric administration
10 mg/kg body weight
Once daily for 10 days
DAU alleviates alcohol-induced liver inflammation and oxidative stress by regulating the p38/NF-κB/NLRP3 inflammasome pathway and reduces hepatic lipid accumulation.
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