Ambeed 大中华区 CN | ZH

中文 - ZH English - EN

Ambeed.cn

搜索

关键字搜索批量搜索

首页 收藏 购物车0
首页 /
抑制剂/激动剂
酶学 囊泡
/
抗感染
酶抑制剂 外泌体
/
NNRTI
反转录酶抑制剂 艾滋病病毒 逆转录酶
/ Dapivirine/达匹韦林

Dapivirine/达匹韦林 {[allProObj[0].p_purity_real_show]}

货号：A175194 同义名： 达匹维林 / TMC120; R147681

Dapivirine是一种 HIV 逆转录酶抑制剂，其 IC50 为 24 nM，对多种病毒有效。

Dapivirine/达匹韦林 化学结构 CAS号：244767-67-7
Dapivirine/达匹韦林 化学结构
CAS号：244767-67-7
Dapivirine/达匹韦林 3D分子结构
CAS号：244767-67-7
Dapivirine/达匹韦林 化学结构 CAS号：244767-67-7
Dapivirine/达匹韦林 3D分子结构 CAS号：244767-67-7
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePriceInt(item.pr_rmb, 1,1) ]}

{[ getRatePriceInt(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]}

{[ getRatePriceInt(item.pr_rmb, 1,1) ]}

{[ getRatePriceInt(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]} 		{[ getRatePriceInt(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_tag_price, item.pr_am) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate,item.mem_isinteger) ]} 现货 1周 咨询 - +
购物车0 收藏 询单

Dapivirine/达匹韦林 纯度/质量文件 产品仅供科研

货号：A175194 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nature, 2025. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
• Cell, 2025. Ambeed. [ A122167 ]
• Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]
• Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]
• Nat. Mater., 2025, 24, 1116-1125. Ambeed. [ A141030 , A131652 ]
更多 >

Dapivirine/达匹韦林 生物活性

描述 Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI). Dapivirine (4-64 μM, 24, 48, 72, 96 and 120 hours) inhibits proliferation of glioma cells and induces apoptosis (16 μM, 12-48 h). Dapivirine (8 and 16 μM, 12 h) enhances invasion of glioma cells. Dapivirine (16 μM, 12 h, 24 h and 48 h) promotes autophagy in U87 cells[3]. Dapivirine apparently blocks infection in the primary cultures at a 10 nM concentration, but secondary cultures revealed that a 100 nM concentration was needed to completely prevent proviral integration[4]. Dapivirine is well tolerated by epithelial cells, T cells, macrophages, and cervical tissue explants with CC50 (50% cytotoxic concentration) of 10 μM to 20 μM. Dapivirine potently inhibits infection by both X4- and R5-utilizing HIV-1 strains with IC50 of 1.46 nM in cell-based assays. Dapivirine potently inhibits HIV-1BaL infection of human ectocervical explant tissue in a dose-dependent manner, as evaluated by the reduction in both p24 release and provirus content in cultured explants. Dapivirine inhibits the transmission of virus to permissive T cells in a dose-dependent manner, with an IC50 of 0.1 nM. Dapivirine results in significant inhibition of HIV infection when explants are challenged with virus immediately with IC90 of 100 nM. Dapivirine is also able to inhibit viral dissemination by migratory cells[5].

Dapivirine/达匹韦林 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01755741 Human Immunodeficiency Virus Phase 1 Completed - United States, California ... 展开 >> California Family Health Council Berkeley, California, United States, 94710 California Family Health Council Los Angeles, California, United States, 90010 收起 <<
NCT03537092 Safety of Vaginal Film Use Phase 1 Recruiting January 2019 United States, Pennsylvania ... 展开 >> Magee womens Hospital of UPMC Recruiting Pittsburgh, Pennsylvania, United States, 15213 Contact: Ingrid Macio, PA-C 收起 <<
NCT03648931 - Recruiting September 2018 Malawi ... 展开 >> Blantyre Clinical Research Site Recruiting Blantyre, Malawi Contact: Frank Taulo, MBBS, MPH, FCOG          Contact       ftaulo@yahoo.com    South Africa Wits Reproductive Health and HIV Institute (WRHI) Clinical Research Site Recruiting Johannesburg, South Africa Contact: Thesla Palanee-Phillips, PhD, MMedSci, MSc          Contact       tpalanee@whri.ac.za    Uganda Makerere University - Johns Hopkins University (MU-JHU) Research Collaboration Clinical Research Site Recruiting Kampala, Uganda Contact: Juliane Etima, BSc, MA Psy          Contact       jetima@mujhu.org    Zimbabwe Zengeza Clinical Research Site Recruiting Harare, Zimbabwe Contact: Petina Musara, BSW          Contact       pmusara@uzchs-ctu.org 收起 <<

Dapivirine/达匹韦林 参考文献

[1]Van Herrewege Y, Michiels J, et al. In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides. Antimicrob Agents Chemother. 2004 Jan;48(1):337-9.

[2]Di Fabio S, Van Roey J, et al. Inhibition of vaginal transmission of HIV-1 in hu-SCID mice by the non-nucleoside reverse transcriptase inhibitor TMC120 in a gel formulation. AIDS. 2003 Jul 25;17(11):1597-604.

[3]Liu W, Song XL, Zhao SC, He M, Wang H, Chen Z, Xiang W, Yi G, Qi S, Liu Y. Antitumor Activity and Mechanism of a Reverse Transcriptase Inhibitor, Dapivirine, in Glioblastoma. J Cancer. 2018 Jan 1;9(1):117-128

[4]Van Herrewege Y, Michiels J, Van Roey J, Fransen K, Kestens L, Balzarini J, Lewi P, Vanham G, Janssen P. In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides. Antimicrob Agents Chemother. 2004 Jan;48(1):337-9

[5]Fletcher P, Harman S, Azijn H, Armanasco N, Manlow P, Perumal D, de Bethune MP, Nuttall J, Romano J, Shattock R. Inhibition of human immunodeficiency virus type 1 infection by the candidate microbicide dapivirine, a nonnucleoside reverse transcriptase inhibitor. Antimicrob Agents Chemother. 2009 Feb;53(2):487-95

Dapivirine/达匹韦林 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.04mL

0.61mL

0.30mL

15.18mL

3.04mL

1.52mL

30.36mL

6.07mL

3.04mL

Dapivirine/达匹韦林 技术信息

CAS号244767-67-7
分子式C20H19N5
分子量 329.4
SMILES Code CC1=C(NC2=CC=NC(NC3=CC=C(C#N)C=C3)=N2)C(C)=CC(C)=C1
MDL No. MFCD09833899
别名 达匹维林 ;TMC120; R147681
运输蓝冰
InChI Key ILAYIAGXTHKHNT-UHFFFAOYSA-N
Pubchem ID 214347
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Keep in dark place, inert atmosphere, 2-8°C
溶解方案

DMSO: 45 mg/mL(136.61 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二

Tags: Dapivirine | TMC120;R147681 | 达匹维林 | Reverse Transcriptase Inhibitor | HIV | Reverse Transcriptase | NNRTI | AmBeed-信号通路专用抑制剂 | Dapivirine/达匹韦林 纯度/质量文件 | Dapivirine/达匹韦林 生物活性 | Dapivirine/达匹韦林 临床数据 | Dapivirine/达匹韦林 参考文献 | Dapivirine/达匹韦林 实验方案 | Dapivirine/达匹韦林 技术信息

AmBeed 相关网站 AmBeed.cn AmBeed.com
AmBeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
    • 客户支持
    技术支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    积分商城
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    AmBeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质用途提供服务。

    尊敬的 AmBeed 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z