Evaluate CsnB's inhibitory effect on UPEC intracellular infection; results showed dose-dependent reduction in intracellular UPEC CFU
Nat Commun. 2024 Sep 27;15(1):8308.
SK-N-BE(2)-C cells
25 μM and 100 μM
18 hours
To evaluate the effect of Cytosporone B on Nurr1 transcription, results showed decreased activity at the highest concentrations
J Med Chem. 2020 Dec 24;63(24):15639-15654.
PC12 cells
25 μM and 100 μM
18 hours
To evaluate the effect of Cytosporone B on Nurr1 transcription, results showed decreased activity at the highest concentrations
J Med Chem. 2020 Dec 24;63(24):15639-15654.
PyMT primary tumor cells
10 μM
24 hours
Inhibited fatty acid uptake and cell proliferation
Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27412-27422.
MCF-7 cells
10 μM
24 hours
Inhibited fatty acid uptake and cell proliferation
Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27412-27422.
HEK293T cells
25 μM and 100 μM
18 hours
To evaluate the effect of Cytosporone B on Nurr1 transcription, results showed decreased activity at the highest concentrations
J Med Chem. 2020 Dec 24;63(24):15639-15654.
TE-1 cells
40 μM
48 hours
Induced cell apoptosis, and IRF1 overexpression attenuated CsnB-induced apoptosis
Cell Death Discov. 2024 May 24;10(1):254.
Kyse520 cells
20, 25, 30, 35, 40 μM
48 hours
Inhibited ESCC cell proliferation, and IRF1 overexpression reversed the suppressive effects of CsnB
Cell Death Discov. 2024 May 24;10(1):254.
Human renal proximal tubular epithelial cells (HK-2 cells)
10 μg/ml
24 hours
To investigate the effect of Csn-B on fibrotic protein expression in HK-2 cells, results showed that Csn-B significantly increased the expression of fibrotic proteins Fn and Col-I.
Mol Med. 2023 May 9;29(1):63.
Cytosporone B 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Mice
UPEC urinary tract infection model
Intraperitoneal injection
5 mg/kg
Started 1 day before infection and continued post-infection
Evaluate CsnB's effect on UPEC bladder infection; significantly reduced IBC formation and bladder bacterial burden
Nat Commun. 2024 Sep 27;15(1):8308.
Mice
MMTV-PyMT mouse model
Intravenous injection
10 mg/kg
Inhibited breast cancer progression
Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27412-27422.
Mice
Cocaine self-administration model
Intraperitoneal injection
10 mg/kg
Single or repeated injections (twice daily for 4 days)
Csn-B attenuated cocaine-induced behavioral responses by activating Nr4a1 and enhanced homeostatic gene transcription
Nat Commun. 2020 Jan 24;11(1):504
Nude mice
HCC xenograft model
Tail vein injection
10 mg/kg
Every three days for three weeks
Csn-B suppresses HCC growth by stimulating WFDC21P expression
Oncogene. 2020 Mar;39(11):2408-2423
BALB/c nude mice
TE-1 xenograft model
Intraperitoneal injection
13 mg/kg
Twice a week until the end of the experiment
Inhibited ESCC tumor growth, and exogenous IRF1 expression significantly diminished the anticancer effect of CsnB
Cell Death Discov. 2024 May 24;10(1):254.
C57BL/6 mice
Unilateral ureteral obstruction (UUO) model
Oral gavage
50 mg/kg
Once every other day starting 7 days before UUO surgery to 7 days after surgery
To investigate the effect of Csn-B on UUO-induced renal interstitial fibrosis, results showed that Csn-B aggravated renal interstitial fibrosis, increased the expression of fibrotic proteins Fn and Col-I, and induced p38 MAPK phosphorylation.
Mol Med. 2023 May 9;29(1):63.
Cytosporone B 实验方案
计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
3.10mL
0.62mL
0.31mL
15.51mL
3.10mL
1.55mL
31.02mL
6.20mL
3.10mL
Cytosporone B 技术信息
CAS号
321661-62-5
分子式
C18H26O5
分子量
322.4
SMILES Code
O=C(OCC)CC1=CC(O)=CC(O)=C1C(CCCCCCC)=O
MDL No.
MFCD12912406
别名
Csn-B; Dothiorelone G
运输
蓝冰
InChI Key
UVVWQQKSNZLUQA-UHFFFAOYSA-N
Pubchem ID
10687292
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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