货号:A2926579
同义名:
重组食蟹猴CD30蛋白(C-6His, HEK293)
/ Recombinant Cynomolgus CD30 (C-6His, HEK293); Tumor necrosis factor receptor superfamily member 8
Recombinant Cynomolgus CD30 (C-6His, HEK293)是来自食蟹猴的CD30蛋白,在HEK293人源细胞中表达,带有C端6×His标签。该蛋白又称TNFRSF8,属于肿瘤坏死因子受体家族,调控细胞增殖/凋亡及抗体应答,主要表达于活化的T、B细胞。其异常表达与系统性肥大细胞增多症、间变性大细胞淋巴瘤及经典霍奇金淋巴瘤的发病相关,也是抗体偶联药物靶向治疗的重要生物标志物。


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| 描述 | CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family, which regulates proliferation/apoptosis and antibody responses. CD30 is expressed by activated, but not by resting, T and B cells. Aberrant expression of CD30 by mastocytosis mast cells and interaction with its ligand CD30L (CD153) appears to play an important role in the pathogenesis and clinical presentation of systemic mastocytosis. CD30 has been considered as a specific diagnostic biomarker of anaplastic large cell lymphoma (ALCL) and classical Hodgkin lymphoma (cHL). CD30 is also a biomarker used for targeted therapy by an antibody–drug conjugate. |
| 蛋白种属 | Cynomolgus |
| 表达系统 | Human Cells |
| 标签 | C-6His |
| 蛋白表达区间 | Met1-Gly194 |
| 蛋白编号 | XP_015298065.1 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 液体 |
| 剂型描述 | Supplied as a 0.2 μm filtered solution of PBS, pH7.4. |
| 复溶 | 如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 20.8 KDa |
| SMILES Code | NONE |
| 别名 | 重组食蟹猴CD30蛋白(C-6His, HEK293) ;Recombinant Cynomolgus CD30 (C-6His, HEK293); Tumor necrosis factor receptor superfamily member 8; CD30L receptor; Ki-1 antigen; Lymphocyte activation antigen CD30; CD30; TNFRSF8 |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 |
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