Curdione, one of the major sesquiterpene compounds from Rhizoma Curcumae, has been shown to exhibit multiple bioactive properties.
Curdione/莪术二酮 细胞实验
Cell Line
Concentration
Treated Time
Description
References
SW480 cells
12.5 μM, 25 μM, 50 μM
48 h
To evaluate the effect of Curdione on SW480 cells. The results showed that Curdione also induced ferroptosis in SW480 cells.
Chin Med. 2023 Sep 21;18(1):122
CT26 cells
12.5 μM, 25 μM, 50 μM
48 h
To evaluate the inhibitory effect of Curdione on the growth of CRC cells. The results showed that Curdione decreased the viability of CT26 cells in a dose-dependent manner, with the lowest cell survival at 50 μM.
Chin Med. 2023 Sep 21;18(1):122
TC-1 cells
100 mg/mL
24 h
Inhibited the mRNA expression of HPV E6 and E7, and suppressed the phosphorylation levels of AKT and ERK1/2 proteins.
Front Immunol. 2025 Jan 22;16:1503355
Dendritic cells (DC 2.4)
100 mg/mL
24 h
Upregulated the mRNA expression levels of IL-12 and IL-23, effectively regulating T cell activation.
Front Immunol. 2025 Jan 22;16:1503355
Macrophages (Raw 264.7)
100 mg/mL
24 h
Inhibited the mRNA expression of IL-6, IL-1β, and TLR4, while promoting the expression of IL-10 and TGF-β, and inhibited the phosphorylation and nuclear translocation of NF-κB p65 protein.
Front Immunol. 2025 Jan 22;16:1503355
Curdione/莪术二酮 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
C57BL/6 mice
Bleomycin (BLM)-induced pulmonary fibrosis model
Intraperitoneal injection
100 mg/kg
Every 2 days for 21 days
To evaluate the therapeutic effect of Curdione on BLM-induced pulmonary fibrosis. Results showed that Curdione significantly alleviated BLM-induced lung injury and fibrosis, and reduced fibroblast to myofibroblast differentiation.
Respir Res. 2020 Feb 19;21(1):58
C57BL/6 mice
MCD feed-induced hepatic fibrosis model
Gavage
50 mg/kg
Once daily for 6 weeks
Curdione significantly alleviated MCD-induced hepatic fibrosis in mice by modulating the TGF-β1/Smad signaling pathway.
Front Cell Dev Biol. 2021 Nov 10;9:763864
Sprague Dawley rats
Middle cerebral artery occlusion (MCAO) model
Intragastric administration
100 mg/kg
Once daily for 7 days before surgery and 14 days after the start of reperfusion
Curdione significantly reduced the infarct size and neurological deficits, promoted cognitive function recovery, and recovered neuronal morphologic damages in MCAO rats. It also blocked the increase of MDA content and elevated the activities of SOD, CAT, and GSH-PX. Moreover, curdione attenuated the expression of Cyt-C, c-caspase-3, and c-caspase-9, increased the Bcl-2/Bax ratio, and hence decreased cellular apoptosis.
Neuropsychiatr Dis Treat. 2017 Jun 30;13:1733-1740
BALB/c nude mice
CT26 subcutaneous transplantation tumor model
Subcutaneous injection
50 mg/kg, 100 mg/kg, 200 mg/kg
Daily administration for 22 days
To evaluate the inhibitory effect of Curdione on tumor growth in CRC mice. The results showed that Curdione significantly inhibited tumor growth, with the therapeutic effect of the high-dose group being close to that of oxaliplatin.
Chin Med. 2023 Sep 21;18(1):122
C57BL/6 mice
LPS/TC-1 cervical orthotopic injection model
Vaginal lavage
100 mg/mL
Once every two days, for a total of seven treatments
Inhibited the secretion of IL-6 and IL-1β, blocked the STAT3-CD274 axis-mediated immune escape, promoted the infiltration and recognition of CD3+CD8+ T cells, and effectively cleared HPV-infected cervical epithelial cells.
搜索
