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/ Cucurbitacin B/葫芦素B

Cucurbitacin B/葫芦素B {[allProObj[0].p_purity_real_show]}

货号：A380132 同义名： Cuc B; NSC 144154

Cucurbitacin B是一种高度氧化的四环三萜，具有抗癌、抗炎和抗氧化活性，通过抑制癌细胞增殖、迁移及诱导细胞凋亡，用于肿瘤与慢性炎症研究。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Cucurbitacin B/葫芦素B 化学结构 CAS号：6199-67-3
Cucurbitacin B/葫芦素B 化学结构
CAS号：6199-67-3
Cucurbitacin B/葫芦素B 3D分子结构
CAS号：6199-67-3
Cucurbitacin B/葫芦素B 化学结构 CAS号：6199-67-3
Cucurbitacin B/葫芦素B 3D分子结构 CAS号：6199-67-3
规格 价格 会员价 库存 数量
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Cucurbitacin B/葫芦素B 纯度/质量文件 产品仅供科研

货号：A380132 标准纯度： {[allProObj[0].p_purity_real_show]}
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Cucurbitacin B/葫芦素B 生物活性

描述 Microtubule, a component of the cytoskeleton, plays crucial roles in various fundamental cell functions, including mitotic regulation, maintenance of cell morphology, intracellular motility and macromolecules and organelles trafficking. Cucurbitacin B, an oxygenated tetracyclic triterpenoid compound extracted from the Thai medicinal plant Trichosanthes cucumerina L., has several biological activities including anti-inflammatory, antimicrobial and anticancer through disruption of the microtubule network. It exhibited a dose-dependent inhibitory effect with the IC50 of 4.12 μM and 3.68 μM for MCF-7 and MDA-MB-231 cells, respectively. In the same cell lines treated with 2.5 μM and 5 μM cucurbitacin B for 24 hr, blockage at G2/M and apoptotic induction were observed in cucurbitacin B-treated cells. Further, cucurbitacin B treatment for 24 hr significantly induced apoptosis approximately 30% to 40% of breast cancer cells population. Compared with the control cells, cucurbitacin B treated cells exhibited obvious aggregation of α-tubulin. The changes were observed within 15 min during incubation with cucurbitacin B[3]. In the nude mice bearing human MDA-MB-231 breast cancer cells, tumor volume was reduced by 55% in the group that received Cucurbitacin B (1.0 mg/kg) for 6 weeks compared with vehicle controls[4].

Cucurbitacin B/葫芦素B 细胞实验

Cell Line
Concentration Treated Time Description References
CRMM2 0.15 μM 72 h Inhibited cell proliferation Acta Pharm Sin B. 2022 Oct;12(10):3861-3876
A549-GR cells 15 nM 48 h Inhibited EMT, decreased EGFR expression and ROS production Chin Med. 2022 Feb 19;17(1):24
A549 cells 5, 10, 15 nM 48 h Inhibited TGF-β1-induced EMT, reversed cell morphology changes, increased E-cadherin expression, decreased N-cadherin and Vimentin expression Chin Med. 2022 Feb 19;17(1):24
CRMM1 0.24 μM 72 h Inhibited cell proliferation Acta Pharm Sin B. 2022 Oct;12(10):3861-3876
CM-AS16 0.08 μM 72 h Inhibited cell proliferation Acta Pharm Sin B. 2022 Oct;12(10):3861-3876
CM2005.1 0.38 μM 72 h Inhibited cell proliferation Acta Pharm Sin B. 2022 Oct;12(10):3861-3876
Huh7 cells 4.1 μM 24 h To evaluate the inhibitory effect of CuB on Huh7 cell proliferation, results showed CuB significantly inhibited cell proliferation ACS Cent Sci. 2022 Aug 24;8(8):1102-1115

Cucurbitacin B/葫芦素B 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
BALB/c nude mice Human lung cancer (A549) xenograft model Intravenous injection 472 nM CuB Every other day for 14 days Evaluate the anticancer effects of CDNVs in vivo, results showed CDNVs significantly inhibited tumor growth without obvious toxicity. Int J Nanomedicine. 2022 Aug 10;17:3583-3599
C57BL/6J mice B16-F10 lung cancer metastasis model Intratracheal administration 0.25 mg/kg, 0.5 mg/kg Once daily for 14 days Inhibited lung cancer metastasis Chin Med. 2022 Feb 19;17(1):24
BALB/c mice H22 xenograft model Intraperitoneal injection 1 or 5 mg/kg Once daily for 14 days To evaluate the anti-HCC effect of CuB in vivo, results showed CuB significantly inhibited tumor growth and promoted immune cell infiltration ACS Cent Sci. 2022 Aug 24;8(8):1102-1115
NCG mice CRMM2 xenograft model Intragastric 1 mg/kg Five times per week for five weeks Significantly inhibited tumor progression without obvious side effects Acta Pharm Sin B. 2022 Oct;12(10):3861-3876

Cucurbitacin B/葫芦素B 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02858388 Otitis Media With Effusion Phase 3 Completed - Italy ... 展开 >> San Gennaro Hospital Naples, Italy, 80136 收起 <<

Cucurbitacin B/葫芦素B 参考文献

[1]Gupta P, Srivastava SK. Inhibition of Integrin-HER2 signaling by Cucurbitacin B leads to in vitro and in vivo breast tumor growth suppression. Oncotarget. 2014 Apr 15;5(7):1812-28.

[2]Shang Y, Guo XX, et al. Cucurbitacin-B inhibits neuroblastoma cell proliferation through up-regulation of PTEN. Eur Rev Med Pharmacol Sci. 2014;18(21):3297-303.

[3]Duangmano S, Sae-Lim P, Suksamrarn A, Domann FE, Patmasiriwat P. Cucurbitacin B inhibits human breast cancer cell proliferation through disruption of microtubule polymerization and nucleophosmin/B23 translocation. BMC Complement Altern Med. 2012;12:185

[4]Wakimoto N, Yin D, O'Kelly J, et al. Cucurbitacin B has a potent antiproliferative effect on breast cancer cells in vitro and in vivo. Cancer Sci. 2008;99(9):1793-1797

Cucurbitacin B/葫芦素B 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.79mL

0.36mL

0.18mL

8.95mL

1.79mL

0.89mL

17.90mL

3.58mL

1.79mL

Cucurbitacin B/葫芦素B 技术信息

CAS号6199-67-3
分子式C32H46O8
分子量 558.7
SMILES Code O[C@H](C1)[C@@]([C@@](C)(O)C(/C=C/C(OC(C)=O)(C)C)=O)([H])[C@](C2)(C)[C@]1(C)[C@]3([H])CC=C4C(C)(C)C([C@@H](O)C[C@@]4([H])[C@]3(C)C2=O)=O
MDL No. MFCD07778083
别名 Cuc B; NSC 144154; NSC 49451
运输蓝冰
InChI Key IXQKXEUSCPEQRD-DKRGWESNSA-N
Pubchem ID 5281316
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Keep in dark place, sealed in dry, 2-8°C
溶解方案

DMSO: 105 mg/mL(187.94 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二

Tags: Cucurbitacin B | 6199-67-3 | Integrin | Autophagy | Cytoskeleton | Autophagy | Apoptosis | Metabolic Enzyme/Protease | Protein Tyrosine Kinase/RTK | Immunology/Inflammation | Integrin | Autophagy | Apoptosis | Endogenous Metabolite | ROS Kinase | COX | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Cucurbitacin B/葫芦素B 纯度/质量文件 | Cucurbitacin B/葫芦素B 生物活性 | Cucurbitacin B/葫芦素B 临床数据 | Cucurbitacin B/葫芦素B 参考文献 | Cucurbitacin B/葫芦素B 实验方案 | Cucurbitacin B/葫芦素B 技术信息

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