Crocin, a natural product isolated and purified from the stigma of Crocus sativus L., can relax smooth muscles with a great potential to be a candidate for the treatment of asthma, protect liver and skeletal muscle tissue against exercise-induced oxidative damage by preventing reactive oxygen species (ROS) production, improve toxic effects of DZN via reducing lipid peroxidation and restoring altered contractile and relaxant responses in rat aorta, protect rat gastric mucosa against ethanol-induced injury via anti-inflammatory, anti-oxidative, anti-apoptotic and mucin-secretagogue mechanisms that are probably mediated by enhanced PGE2 release, significantly inhibit the growth of HO-8910 cells and arrest them in the G0/G1 phase, and also promote ovarian cancer HO-8910 cell apoptosis, most likely by increasing p53 and Fas/APO-1 expression, and then activating the apoptotic pathway regulated by Caspase-3.
Crocin/西红花苷 细胞实验
Cell Line
Concentration
Treated Time
Description
References
HUVEC cells
10, 20, 40 µg/mL
24 h
Crocin significantly reduced the viability of HUVEC cells.
Cells. 2022 Apr 29;11(9):1502.
HCEC cells
10, 20, 40 µg/mL
24 h
Crocin was not toxic to normal human colonic epithelial cells (HCEC).
Cells. 2022 Apr 29;11(9):1502.
Caco-2 cells
10, 20, 40 µg/mL
24 h
Crocin significantly reduced the viability of Caco-2 cells and was not toxic to normal human colonic epithelial cells (HCEC).
Cells. 2022 Apr 29;11(9):1502.
HT-29 cells
10, 20, 40 µg/mL
24 h
Crocin significantly reduced the viability of HT-29 cells and was not toxic to normal human colonic epithelial cells (HCEC).
Cells. 2022 Apr 29;11(9):1502.
Crocin/西红花苷 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Nude mice
Colon cancer model
Oral gavage
50, 100, 150 mg/kg
Five times a week, continuous treatment
Crocin at 150 mg/kg significantly inhibited tumour angiogenesis and tumour growth.
Cells. 2022 Apr 29;11(9):1502.
Male albino BABL/c mice
Repetitive mild traumatic brain injury (rmTBI) mouse model
Intraperitoneal injection
30 mg/kg
Administered 30 min before each injury, total of 7 injuries with 48 h intervals
To evaluate the neuroprotective effects of crocin in a rmTBI mouse model. Results showed that crocin significantly improved neurological, cognitive, motor, and sensorimotor functions, and reduced oxidative stress and inflammatory processes.
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