To assess CMA's ability to induce interferon in L cells; no antiviral activity was detected.
Antimicrob Agents Chemother. 1980 Jul;18(1):20-6.
Cridanimod/吖啶酮乙酸 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Swiss albino mice and Syrian hamsters
Young and adult Swiss albino mice, congenitally asplenic mice, and one-week-old Syrian hamsters
Intraperitoneal (i.p.), subcutaneous (s.c.), intramuscular (i.m.), and oral (p.o.) by gavage
Mice: 56 to 2,240 mg/kg; Hamsters: 620 to 1,550 mg/kg
Single dose, observation up to 24 hours
To evaluate CMA's ability to induce interferon in mice and hamsters. Results showed rapid induction of high interferon levels in mice (up to 400,000 U/mL), while lower levels were induced in hamsters (up to 6,400 U/mL).
Antimicrob Agents Chemother. 1980 Jul;18(1):20-6.
CD-1 mice
Venezuelan equine encephalitis virus infection model
Intragastric
123 mg/kg
Once daily for 10 days
Cridanimod and Tilorone show the antiviral activity in mice and rats and protect the mice from death. In rats, both drugs diminish the viremia
Pharmaceuticals (Basel). 2022 May 17;15(5):617
Wistar rats
Venezuelan equine encephalitis virus infection model
Intragastric
62 mg/kg
Once daily for 10 days
Cridanimod and Tilorone show the antiviral activity in mice and rats and protect the mice from death. In rats, both drugs diminish the viremia
Pharmaceuticals (Basel). 2022 May 17;15(5):617
Mice
VEEV infection model
Intragastric administration
123 mg/kg
Once daily for ten days
Evaluate the protective effect of Cridanimod in mice, showing 60% survival.
Pharmaceuticals (Basel). 2022 May 17;15(5):617
Mice
Wild-type mice
Intraperitoneal injection
250 µg/mL
2 hours
Used as a positive control to study the effect of STING agonist on thymocyte apoptosis
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