Coixol is a natural product isolated and purifed from the seeds of Coix lacryma-jobi L. var. meyuan (Romen.) Stapf. Coixol acts as a central muscle relaxant with an anti-convulsant effect, interacts with the pituitary to stimulate reproduction in voles. It also interacts with FSH to stimulate follicular development and increase ovulation. Coixol can regulate gene expression, production and secretion of mucin, by directly acting on airway epithelial cells.
Coixol 细胞实验
Cell Line
Concentration
Treated Time
Description
References
B16F10 melanocytes
5, 10, 15 μg/mL
30 min
To inhibit tyrosinase activity, results showed that Coixol significantly inhibited tyrosinase activity with an inhibition rate of 75.3% at 15 μg/mL
Molecules. 2022 Jul 20;27(14):4626
RAW 264.7 cells
400 and 800 μM
8 h
To evaluate the inhibitory effect of Coixol on the expression of inflammatory mediators in LPS-induced RAW 264.7 cells. Results showed that Coixol significantly reduced the expression of IL-1β, IL-6, TNF-α, NO, iNOS, and COX-2, but had no effect on the expression of IL-10.
Molecules. 2020 Feb 18;25(4):894
Coixol 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Brandt's voles (Lasiopodomys brandtii)
Adult male Brandt's voles
Intragastric administration
1 mg/kg and 2 mg/kg
Every 2 days for 15 days
6-MBOA inhibited the growth of voles. A low dose of 6-MBOA increased the species richness of cecal microbiota, altered the microbial community structure, enhanced the abundance of certain bacteria, inhibited glucose metabolism and protein digestion and absorption, stimulated butyrate production, and enhanced the metabolism of xenobiotics.
Front Microbiol. 2022 Mar 29;13:847073
Mice
Ischemia/reperfusion-induced acute kidney injury model
Intraperitoneal injection
20 mg/kg
Injected once three days, two days, and one day before surgery
Coixol significantly reduced serum creatinine and blood urea nitrogen levels, decreased the expression of KIM1 and NGAL, and alleviated acute kidney injury by suppressing cellular senescence
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