Choline chloride is an essential nutrient known for activating alpha7 nicotinic receptors and possesses analgesic and anti-inflammatory properties. It is influential in addressing conditions like liver disease, atherosclerosis, and neurological disorders[1].[2].
体内研究
Subcutaneously administered at doses of 0.2 and 100 mg/kg/h for either 24 or 48 hours, it significantly diminishes postoperative injurious reflexes and lowers tumor necrosis factor (TNF) release from macrophages in female C57/Bl6 mice[2].
体外研究
When administered at concentrations of 0 or 70 μM for four days, choline chloride effectively reduces apoptosis and enhances cell viability[1].
Choline chloride/氯化胆碱 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Lactiplantibacillus plantarum BCRC 10357
1%, 3%, 5%
12-48 h
To evaluate the effect of choline chloride on the β-glucosidase activity of Lactiplantibacillus plantarum BCRC 10357. Results showed that 1% choline chloride stimulated the highest β-glucosidase activity (19.47 U/mL) at 12 h of incubation.
Foods. 2023 Oct 14;12(20):3781
Choline chloride/氯化胆碱 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Rats
Adrenal denervation model
Stomach tube
20 mmol/kg
Single dose or daily administration for 4 days
To study the effect of choline chloride on adrenal tyrosine hydroxylase activity, results showed a 51% increase in enzyme activity after 4 days of daily administration
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