Cephalotin (Cephalotin) is a beta-lactam antibiotic, inhibits class C β-lactamase AmpC, with an Ki of 0.32 µM[1]. The maximum plasma cephalothin concentration after IM administration was 11.3 +/- 3.71 micrograms/ml. The terminal half-life was 47.0 minutes and was longer than the half-life after IV administration. The bioavailability of cephalothin given IM ranged from 38.3% to 93.1% and averaged 65.0 +/- 20.5%[2]. Two derivatives of cephalothin, compound I and II, were synthesized and demonstrated strong growth inhibition of ampicillin resistant Escherichia coli (E. coli). The MIC50 of I and II were determined to be 55 microg/mL and 30 microg/mL, respectively. Cephalothin showed less than 20% growth inhibition of E. coli at all concentrations based on assay of colony forming units. Compounds I and II showed greater than 50% growth inhibition of E. coli at all concentrations greater than 50 microg/mL (more than 65% at 400 microg/mL)[3]. Patients receiving intravenous sodium cephalothin or intravenous penicillin-G. Immunogenicity was indicated by a higher incidence of anti-cephalothin antibody in patients after having received the drug than in controls and by an increase in titre of anti-cephalothin antibody during administration of the drug. Further, patients receiving cephalothin had a high incidence of anti-penicillin antibodies and the anti-penicillin antibody titre increased during cephalothin administration[4].
Cephalothin/头孢噻吩 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Fusobacterium nucleatum
0.01 mg/mL
3.5 h or 24 h
Construct phenotypic fingerprints via flow cytometry to predict the mechanism of action of cephalothin. Results showed that the mechanism of action of cephalothin was successfully predicted as the 'Cell Wall Synthesis' class.
Microbiol Spectr. 2024 Apr 2;12(4):e0393123
Actinomyces viscosus
0.01 mg/mL
3.5 h or 24 h
Construct phenotypic fingerprints via flow cytometry to predict the mechanism of action of cephalothin. Results showed that the mechanism of action of cephalothin was successfully predicted as the 'Cell Wall Synthesis' class.
Microbiol Spectr. 2024 Apr 2;12(4):e0393123
Bordetella bronchiseptica
32 μg/ml
16 to 20 h
To determine the antimicrobial activity of cephalothin against Bordetella bronchiseptica isolates from swine respiratory tract infections, showing that the MIC90 was 32 μg/ml.
Evaluated the synergy of cephalothin with amikacin, showing synergistic effect in 26.9% and partially synergistic in 73.07% of isolates
Ann Clin Microbiol Antimicrob. 2006 Oct 12;5:25
Cephalothin/头孢噻吩 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Insect larvae (Galleria mellonella)
MRSA-infected insect larva model
Injection
30 mg/kg
Every 6 hours for up to 84 hours
To evaluate the combined therapeutic effect of Cephalothin with the quorum-sensing inhibitor F12, results showed that combination therapy significantly increased the survival time of MRSA-infected insect larvae.
搜索
