Cefuroxime sodium is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. It is against Staphylococcus aureus methicillin susceptible; S. aureus, methicillin resistant; Streptococcus pyogenes; S. pneumonia; S. viridans; S. faecalis and Clostridium spp with MIC values of 0.25 μg/ml, 5.9 μg/ml, 0.125 μg/ml, 0.125 μg/ml, 0.125 μg/ml, >125.0 μg/ml, and 1.2 μg/ml, respectively. It is highly active against Neisseria gonorrhoeae, Neisseria meningitidis, and also Haemophilus influenzae, including ampicillin-resistant strains. Cefuroxime is rapidly bactericidal and induces the formation and subsequent lysis of filamentous forms over a small concentration range[2]. Rabbits (weighing 2.0 to 2.5 kg) are challenged intravenously with S. aureus strain 630 (a penicillinase-producing strain), the median effective dose of Cefuroxime sodium is 3 mg/kg as a result of the protection test[3]. After both i.v. and intramuscular injections of cefuroxime sodium, the concentrations of cefuroxime in urine were much higher than that in serum. The systemic bioavailability of cefuroxime sodium in goats after intramuscular injections of 20 and 40 mg/kg body weight was 88.4 percent and 103.5 percent, respectively. In vitro protein binding of cefuroxime sodium in goat's serum was low, ranging from 13.3 percent to 21.6 percent with an average of 17.0 percent[4].
Spain
... 展开 >> Faculty of Health Sciences. University of Granada.
Recruiting
Granada, Spain, 18071
Contact: M. Carmen , Ph, MD 958 248035
Principal Investigator: M. Carmen Valenza, Ph, MD 收起 <<
China, Guizhou
... 展开 >> children's hospital of Guiyang
Guiyang, Guizhou, China, 550000
Affiliated Hospital of Zunyi Medical University
Zunyi, Guizhou, China, 563000
The first people hospital of zunyi
Zunyi, Guizhou, China, 563000 收起 <<
Israel
... 展开 >> Dep of OG/GYN, Emek Medical Center
Recruiting
Afula, Israel
Contact: MEIRAV BRAVERMAN, MD 0509384595 meiraval@clalit.org.il
Principal Investigator: Meirav Braverman, MD 收起 <<
United States, Kentucky
... 展开 >>
University of Louisville
Recruiting
Louisville, Kentucky, United States, 40202
Contact: Julio A Ramirez, MD 502-852-1148 jarami01@louisville.edu
Contact: David Seligson, MD 502-852-0923 d0seli01@louisville.edu
Sub-Investigator: Forest Arnold, DO
Sub-Investigator: Timothy Wiemkwn, PhD
Sub-Investigator: Robert Kelley, PhD
Sub-Investigator: James Summersgill, PhD
Sub-Investigator: Ruth Carrico, PhD
Sub-Investigator: Julie Harting, PharmD
Sub-Investigator: Paula Peyrani, MD
Principal Investigator: David Seligson, MD
Sub-Investigator: Craig Roberts, MD
Principal Investigator: Julio Ramirez, MD 收起 <<
Spain
... 展开 >> Jerez de la Frontera Hospital
Recruiting
Jerez de la Frontera, Cádiz, Spain, 11138
Contact: Salvador Pérez Cortes, MD salvador.perez.cortes.sspa@juntadeandalucia.es
La Línea de La Concepción Hospital
Terminated
La Línea de La Concepción, Cádiz, Spain
University Hospital Donostia
Recruiting
San Sebastian, Gipúzcoa, Spain, 20080
Contact: Maialen Ibarguren Pinilla, MD MAIALEN.IBARGURENPINILLA@osakidetza.eus
Cruces Hospital
Recruiting
Baracaldo, País Vasco, Spain
Contact: Josune Goikoetxea Agirre ANEJOSUNE.GOIKOETXEAAGIRRE@osakidetza.net
San Juan de Dios del Aljarafe Hospital
Terminated
Bormujos, Sevilla, Spain, 41930
University General Hospital of Alicante
Recruiting
Alicante, Spain, 03012
Contact: Esperanza Merino de Lucas, MD merino_luc@gva.es
University Hospital Mutua de Tarrasa
Recruiting
Barcelona, Spain, 08221
Contact: Lucía Gómez García, MD lgomez@mutuaterrassa.es
University Hospital of Bellvitge
Recruiting
Barcelona, Spain
Contact: Guillermo Cuervo Requena guillermocuervo@hotmail.com
University Hospital Puerta del Mar
Recruiting
Cádiz, Spain, 11009
Contact: Francisca Guerrero Sánchez, MD, PhD fcam.gs@gmail.com
Puerto Real Hospital
Recruiting
Cádiz, Spain
Contact: Patricia Jimenez, MD patriciajaguilar@gmail.com
La Coruña Hospital
Recruiting
La Coruña, Spain
Contact: German Bou Arévalo germanbou@canalejo.org
Universitary Hospital of Leon
Recruiting
León, Spain
Contact: Jose Manuel Guerra Laso jmglaso@gmail.com
University Hospital La Princesa
Recruiting
Madrid, Spain, 28002
Contact: Ana Salas Aparicio, MD asalasapa@yahoo.es
University Hospital La Paz
Recruiting
Madrid, Spain, 28046
Contact: Belen Loeches Yagüe, MD, Ms.C bloeches@yahoo.es
Universitary Hospital of Orense
Recruiting
Orense, Spain
Contact: MªDolores Díaz Lòpez Maria.Dolores.Diaz.Lopez@sergas.es
Son Espases Hospital
Recruiting
Palma de Mallorca, Spain, 07010
Contact: Mª Luisa Martín Pena, MD lmartinpena@ssib.es
University Clinic of Navarra
Recruiting
Pamplona, Spain, 31008
Contact: José Ramón Yuste Ara, MD, PhD
University Hospital Marqués de Valdecilla
Recruiting
Santander, Spain, 30008
Contact: Mª Carmen Fariñas Álvarez, MD, PhD mcfarinas@humv.es
University Hospital Virgen Macarena
Recruiting
Seville, Spain, 41071
Contact: Luis Eduardo López Cortés, MD, PhD luiselopezcortes@gmail.com
Universitary Hospital of Vigo
Recruiting
Vigo, Spain
Contact: MªTeresa Pérez Rodriguez maria.teresa.perez.rodriguez2@sergas.es
University Hospital of Zaragoza
Recruiting
Zaragoza, Spain, 28046
Contact: José Ramón Paño Pardo, MD, PhD joserrapa@gmail.com 收起 <<
United States, Arizona
... 展开 >>
Barrow Brain and Spine
Recruiting
Phoenix, Arizona, United States, 85013
Contact: Heidi Jahnke, RN,MSN 602-406-6976 heidi.jahnke@dignityhealth.org
Principal Investigator: Andrew Little, MD
Principal Investigator: James Evans, MD
Principal Investigator: Varun Kshettry, MD 收起 <<
Korea, Republic of
... 展开 >>
Joint Reconstruction Center, Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, Korea, Republic of, 463-707 收起 <<
India
... 展开 >> Ganga Hospital, Orthopaedics Department
Recruiting
Coimbatore, Tamil Nadu, India, 641043
Contact: Janardhan Yerramshetty, Ph.D. 0422-2485000 jyerram@gmail.com
Principal Investigator: Rajasekaran Shanmuganathan, Ph.D. 收起 <<
United States, California
... 展开 >>
Univ of California / San Diego Treatment Ctr
San Diego, California, United States, 921036325
Stanford at Kaiser / Kaiser Permanente Med Ctr
San Francisco, California, United States, 94115
United States, New York
Montefiore Drug Treatment Ctr / Bronx Municipal Hosp
Bronx, New York, United States, 10461
Montefiore Family Health Ctr / Bronx Municipal Hosp
Bronx, New York, United States, 10461
Samaritan Village Inc / Bronx Municipal Hosp
Bronx, New York, United States, 10461
Jack Weiler Hosp / Bronx Municipal Hosp
Bronx, New York, United States, 10465
Montefiore Med Ctr / Bronx Municipal Hosp
Bronx, New York, United States, 10467
Montefiore Med Ctr Adolescent AIDS Program
Bronx, New York, United States, 10467
North Central Bronx Hosp / Bronx Municipal Hosp
Bronx, New York, United States, 10467
United States, Pennsylvania
Thomas Jefferson Univ Hosp
Philadelphia, Pennsylvania, United States, 191075098 收起 <<
United States, California
... 展开 >>
Olive View-UCLA Medical Center
Recruiting
Sylmar, California, United States, 91342
Contact: Anusha Krishnadasan idnet@ucla.edu
Principal Investigator: David Talan, MD
Harbor-UCLA Medical Center
Recruiting
Torrance, California, United States, 90509
Contact: Anusha Krishnadasan idnet@ucla.edu
Principal Investigator: Amy Kaji, MD
United States, Colorado
University of Colorado Denver
Not yet recruiting
Aurora, Colorado, United States, 80045
Contact: Tracey MacDermott 303-724-2757 Tracey.MacDermott@ucdenver.edu
Principal Investigator: Lisa Ferrigno, MD
United States, Illinois
Rush University Medical Center
Not yet recruiting
Chicago, Illinois, United States, 60612
Contact: Saketh Nadimpalli 312-942-1735 saketh_nadimpalli@rush.edu
Principal Investigator: Thea Price, MD
United States, Iowa
University of Iowa Hospitals and Clinics
Recruiting
Iowa City, Iowa, United States, 52242
Contact: Cathy Fairfield 319-384-8335 catherine-fairfield@uiowa.edu
Principal Investigator: Brett Faine, PharmD, MS
United States, Maine
Maine Medical Center
Recruiting
Portland, Maine, United States, 04102
Contact: Deb Burris 207-662-2467 burrid@mmc.org
Principal Investigator: Damien Carter, MD
United States, Massachusetts
Boston Medical Center
Recruiting
Boston, Massachusetts, United States, 02118
Contact: Melissa Griswold 617-414-6836 Melissa.griswold@bmc.org
Principal Investigator: Frederick Drake, MD
Principal Investigator: Sabrina Sanchez, MD
Beth Israel Deaconess Medical Center
Recruiting
Boston, Massachusetts, United States, 02215
Contact: Ellie Rosseto 617-754-2332 erosseto@bidmc.harvard.edu
Principal Investigator: Nathan Shapiro, MD
United States, Michigan
Michigan Medicine- University of Michigan
Recruiting
Ann Arbor, Michigan, United States, 48109
Contact: Sinan Hanna 734-232-3813 sinanh@med.umich.edu
Principal Investigator: Hasan Alam, MD
Henry Ford Health System
Recruiting
Detroit, Michigan, United States, 48202
Contact: Lillian Hayes 313-916-8006 lhayes4@hfhs.org
Principal Investigator: Jeffrey Johnson, MD
United States, Mississippi
University of Mississippi Medical Center
Recruiting
Jackson, Mississippi, United States, 39216
Contact: Deepti Patki 601-815-3008 dpatki@umc.edu
Principal Investigator: Alan Jones, MD
United States, New York
New York University - Bellevue Hospital
Active, not recruiting
New York, New York, United States, 10016
New York University - Tisch Hospital
Active, not recruiting
New York, New York, United States, 10016
Columbia University Medical Center
Recruiting
New York, New York, United States, 10032
Contact: Lyn Goldsmith 212-342-0261 lg2240@cumc.columbia.edu
Principal Investigator: Katherine Fischkoff, MD
United States, Ohio
The Ohio State University Medical Center
Recruiting
Columbus, Ohio, United States, 43210
Contact: Kristina Zottola 614-292-7146 Kristina.Zottola@osumc.edu
Principal Investigator: Steven Steinberg, MD
United States, Tennessee
Vanderbilt University Medical Center
Recruiting
Nashville, Tennessee, United States, 37232
Contact: Brittney Jackson 615-343-1980 Brittney.e.jackson@vanderbilt.edu
Principal Investigator: Wesley Self, MD
United States, Texas
Lyndon B Johnson- Harris Health
Recruiting
Houston, Texas, United States, 77026
Contact: Debbie Lew, MPH 713-566-5097 debbie.f.lew@uth.tmc.edu
Principal Investigator: Mike K Liang, MD
The University of Texas Health Science Center at Houston
Recruiting
Houston, Texas, United States, 77026
Contact: Garrett Jost Garrett.B.Jost@uth.tmc.edu
Principal Investigator: Lillian Kao, MD
United States, Washington
Providence Regional Medical Center Everett
Recruiting
Everett, Washington, United States, 98201
Contact: Tija Schmiesing, MHA 425-261-4075 Tija.Schmiesing@Providence.org
Principal Investigator: Careen Foster, MD
Harborview Medical Center
Recruiting
Seattle, Washington, United States, 98104
Contact: Erin Carney 206-685-9770 ecarney@uw.edu
Sub-Investigator: Heather L Evans, MD, MS
Sub-Investigator: Amber Sabbatini, MD, MPH
Virginia Mason University Village Medical Center
Recruiting
Seattle, Washington, United States, 98105
Contact: Adrian Parker 206-341-1021 Adrian.parker@virginiamason.org
Principal Investigator: Richard Thirlby, MD
Swedish Medical Center- First Hill
Recruiting
Seattle, Washington, United States, 98122
Contact: Julie Wallick 206-215-3986 Julie.Wallick@swedish.org
Principal Investigator: Katherine A Mandell, MD, MPH
University of Washington Medical Center
Recruiting
Seattle, Washington, United States, 98195
Contact: Erin Carney 206-685-9770 ecarney@uw.edu
Sub-Investigator: Giana H Davidson, MD, MPH
Sub-Investigator: Amber Sabbatini, MD, MPH
Madigan Army Medical Center
Active, not recruiting
Tacoma, Washington, United States, 98431 收起 <<
Austria
... 展开 >> University Eye Clinic, Paracelsus Private Medical University
Salzburg, Austria
Belgium
University Hospital Antwerp, UZA Ophthalmology
Antwerp, Belgium
University of Gent, Universitaire Zeikenhuis
Gent, Belgium
Jan Yperman Ziekenhuis
Ieper, Belgium
Centre Hospitalier Universitaire
Liege, Belgium
Oogheelkunde
Melveren, Belgium
Germany
Augenklinik Ahaus
Ahaus, Germany
Italy
Azienda Ospedaliera di Desenzano del Garda
Desenzano, Italy
Ospedale Borgo Trento
Verona, Italy
Poland
Kierownik Katedry i Kliniki
Warsaw, Poland
Portugal
University Hospital
Coimbra, Portugal
Spain
Instituto Oftalmologico VISSUM
Alicante, Spain
La Candelaria University Hospital
La Candelaria, Tenerife, Spain
Hospital Universitario de Canarias
La Laguna, Tenerife, Spain
Hospital Oftalmologico Internacional
Madrid, Spain
Turkey
Dokuz Eylul University
Izmir, Turkey
United Kingdom
Axminster Hospital
Axminster, United Kingdom
West of England Eye Unit, Royal Devon & Exeter Hospital (Wonford)
Exeter, United Kingdom
Ipswich Hospital
Ipswich, United Kingdom
Moorfields Eye Outreach Unit, Northwick Park Hospital
London, United Kingdom
Moorfields Eye Outreach Unit, St. George's Hospital
London, United Kingdom
St. Thomas' Hospital
London, United Kingdom
Oxford Eye Hospital
Oxford, United Kingdom
Sunderland Eye Infirmary
Sunderland, United Kingdom 收起 <<
Urinary Tract Infections in Ch... 展开 >>ildren 收起 <<
Not Applicable
Recruiting
January 31, 2020
Poland
... 展开 >> Children's Hospital for The Medical University of Warsaw
Recruiting
Warsaw, Poland, 02-091
Contact: Maria Daniel, MD 696477117 ext 0048 maria.daniel@wum.edu.pl
The Holy Family Specialistic Hospital
Recruiting
Warsaw, Poland, 02-544
Contact: Maria Daniel, MD 收起 <<
China, Shanghai
... 展开 >>
Department of Pharmacy, Xinhua Hospital, Shanghai Jiaotong University School of Medicine.Kongjiang Road 1665,
Recruiting
Shanghai, Shanghai, China, 200092
Contact: Li lixia, Master llxlyy88@sina.com 收起 <<
Infection Prophylaxis in Colo ... 展开 >>Rectal Surgery 收起 <<
Phase 4
Completed
-
Sweden
... 展开 >> Department of Surgery, University hospital Sahlgrenska/Östra
Gothenburg, Sweden, 416 85
Department of Surgery and oncology, Halland Hospital in Halmstad
Halmstad, Sweden, 301 85
Department of surgery, Community Hospital i Karlskrona
Karlskrona, Sweden, 371 85
Vrinnevi hospital
Norrköping, Sweden, 601 82
Department of surgery
Skövde, Sweden, 541 85
Department of Surgery, NU-hospitals
Uddevalla, Sweden, 451 80 收起 <<
United States, New Jersey
... 展开 >>
Sanofi-Aventis
Bridgewater, New Jersey, United States
Belgium
Sanofi-Aventis
Brussels, Belgium
France
Sanofi-Aventis
Paris, France
Hungary
Sanofi-Aventis
Budapest, Hungary
Morocco
Sanofi-Aventis
Casablanca, Morocco
Spain
Sanofi-Aventis
Barcelona, Spain
Tunisia
Sanofi-Aventis
Megrine, Tunisia
Turkey
Sanofi-Aventis
Istanbul, Turkey 收起 <<
Terminated(Pediatric developme... 展开 >>nt program terminated by sponsor) 收起 <<
-
United States, New Jersey
... 展开 >>
Sanofi-Aventis Administrative Office
Bridgewater, New Jersey, United States, 08807
France
Sanofi- Aventis Administrative Office
Paris, France 收起 <<
The Patients Who Receive Percu... 展开 >>taneous Endoscopic Gastrostomy
Peristomal Wound Infection After the Operation of PEG
Prophylactic Antibiotics Before PEG 收起 <<
Not Applicable
Unknown
August 2011
Taiwan
... 展开 >> National Cheng Kung University Hospital
Recruiting
Tainan, Taiwan, 704
Contact: chiaohsiung chuang, M.D. 88662353535 ext 2679 chuang.chiaohsiung@gmail.com
Principal Investigator: chiao-hsiung chuang, M.D. 收起 <<
Slovenia
... 展开 >> Institute of Microbiology and Immunology, Medical Faculty, University of Ljubljana
Ljubljana, Slovenia, 1000
Department of Infectious Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia
Ljubljana, Slovenia, 1525 收起 <<
Belgium
... 展开 >> Ghent University Hospital
Recruiting
Ghent, Belgium, 9000
Contact: Jan De Waele, MD, PhD Jan.DeWaele@ugent.be
Principal Investigator: Jan De Waele, MD, PhD 收起 <<
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