There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Ceftriaxone sodium (trihydrate), one of the beta-lactam antibiotics, is a third-generation semi-synthetic antibiotic belonging to the class of cephalosporins. It has bactericidal action; its main activity is related to the Gram-negative bacteria, being also able to act against Gram-negative bacilli resistant to the first- and second-generation cephalosporins[2]. Ceftriaxone is a stimulator of EAAT2 (Excitatory amino acid transporter2) expression with neuroprotective effects in both in vitro and in vivo models based in part on its ability to inhibit neuronal cell death by glutamate excitotoxicity[3]. Long term ceftriaxone sodium administration resulted in gut microbiota dysbiosis, intestine histological lesions, growth inhibition, spleen index reducing. Not only the immune defense, long term ceftriaxone administration also affected immune regulation[4].
Ceftriaxone sodium hydrate/头孢曲松钠 细胞实验
Cell Line
Concentration
Treated Time
Description
References
THP-1 monocytes
4 mg/L
7 days
Evaluated the bactericidal effect of ceftriaxone on intracellular MAC, showing EC50 of 0.20-0.25 times MIC and maximal kill of 1.16-1.96 log10 CFU/mL.
J Infect Dis. 2024 Aug 16;230(2):e230-e240.
Ceftriaxone sodium hydrate/头孢曲松钠 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Male Sprague Dawley rats
Cocaine self-administration followed by abstinence model
Intraperitoneal injection
100 and 200 mg/kg
Once daily for 6 days
To investigate the effects of ceftriaxone on context-primed relapse following abstinence and its impact on AMPA receptor subunit expression in the NAc. Results showed that both doses of ceftriaxone attenuated relapse and reduced GluA1 expression in the NAc, but did not affect GluA2 expression.
Eur Neuropsychopharmacol. 2016 Feb;26(2):186-194
Sprague-Dawley rats
6-hydroxydopamine (6-OHDA) Parkinson’s disease model
Intraperitoneal injection
200 mg/kg
Seven consecutive daily injections
Ceftriaxone increased GLT-1 expression and glutamate uptake, reduced tyrosine hydroxylase (TH) loss induced by 6-OHDA, and decreased amphetamine-induced rotation behavior.
Mol Neurobiol. 2014 Jun;49(3):1282-92
Sprague-Dawley rats
Subcutaneous injection model
Subcutaneous injection
1000 mg/kg
Once daily for 12 days
To evaluate the local tolerability of subcutaneous ceftriaxone administration. Results showed that the local tissue response was remarkably reduced when the same ceftriaxone dose was given at a lower concentration (25 mg/ml) over a longer period of time (120 min).
Antimicrob Agents Chemother. 2020 Feb 21;64(3):e02090-19
Swiss albino mice
Cecal ligation and puncture (CLP)-induced sepsis model
Subcutaneous injection
100 mg/kg
Single dose, 3 hours post-CLP
To evaluate the protective effect of ceftriaxone in a sepsis model, results showed that ceftriaxone alone reduced bacterial load but did not significantly improve survival.
Inflammation. 2020 Jun;43(3):1035-1043
Mice
Tsc1GFAPCKO mouse model
Intraperitoneal injection
200 mg/kg
Daily until death or the pre-defined endpoint of the experiment
Early treatment (before seizure onset) increased astrocyte glutamate transporter expression, decreased extracellular glutamate levels, neuronal death, and seizure frequency, and improved survival; late treatment (after seizure onset) increased glutamate transporter expression but had no effect on seizures.
Neurobiol Dis. 2010 Mar;37(3):764-71
Mice
Epilepsy model
Intraperitoneal injection
200 mg/kg
Daily
Evaluate the antiepileptic effect of ceftriaxone in epilepsy models
J Exp Med. 2017 Feb;214(2):547-563
Mice
Pneumococcal meningitis model
Intraperitoneal
100 mg/kg
Daily starting from 16 hours after infection
To evaluate the therapeutic effect of ceftriaxone on pneumococcal meningitis, results showed no significant difference in mortality between the ceftriaxone-treated group and the placebo group.
J Neuroinflammation. 2019 Dec 28;16(1):279
BALB/c mice
Systemic lupus erythematosus model
Oral gavage
400 mg/kg
Once daily for 5 consecutive days
To reduce pre-existing bacteria populations to boost the proliferation of intestinal microorganisms from donor animals post-FMT
Antioxidants (Basel). 2021 Sep 7;10(9):1426
BALB/c mice
Vaginal infection model
Intraperitoneal
15 mg/kg
Single dose
To evaluate the therapeutic effect of ceftriaxone on vaginal infection in mice, results showed all mice cleared the infection within 24 hours after treatment.
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