Calcipotriol is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor.
Calcipotriol/卡泊三醇 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Human rectal epithelial cells
1 µM
15 hours
Calcipotriol reduced crypt cell production rate by 52% from mean (SEM) 5-29(1.18) to 256(0.80)cells/crypt/hour (p<0.01)
Gut. 1994 Dec;35(12):1742-6.
HepG2 cells
0.1, 1, 10 nM
2 hours
To investigate the impact of CYP3A4 on the VDR-induction ability of 1,25(OH)2D3, results showed that CYP3A4 inhibited the induction of VDR by 1,25(OH)2D3
To investigate the effects of vitamin D and testosterone on muscle differentiation, results showed that testosterone enhanced the inducing effects of VD on VDR, AR, P-AKT, PGC1α, Beclin1 and LC3B
To assess the inhibitory effect of Calcipotriol on FDM development. Results showed that Calcipotriol significantly suppressed FDM-induced myopia progression and upregulated scleral Col1α1 gene expression levels.
Invest Ophthalmol Vis Sci. 2023 Feb 1;64(2):2.
C57BL/6 mice
MC903-induced skin inflammation model
Topical application
0.5 nmol/ear
Daily for 14 days
To investigate the protective effect of DMOG on MC903-induced skin inflammation. DMOG significantly attenuated MC903-induced skin inflammation, accompanied by downregulation of TSLP and IL-33.
Front Immunol. 2024 Mar 1;15:1330011
C57BL/6J mice
Nur77 knockout mice
Intraperitoneal injection
60 µg/kg
Three times a week for a total of 12 weeks
Calcipotriol combined with iBRD9 treatment reduced the body weight and body fat percentage in Nur77 knockout mice, regulated the gut microbiota, improved intestinal mucosal barrier function, reduced LPS absorption into the blood, and alleviated obesity
Int J Obes (Lond). 2020 May;44(5):1052-1061
BALB/c-nude mice
Gastric cancer xenograft model
Intraperitoneal injection
60 mg/kg
Three times a week for 16 days
Significantly inhibited tumor growth and enhanced the anti-tumor effect of oxaliplatin
Acta Pharmacol Sin. 2023 Jan;44(1):178-188.
Mice
Sod1 knockout mice (SKO)
Intraperitoneal injection
60 μg/kg
Three times a week, lasting until 28 weeks of age
To investigate the effects of Calcipotriol on muscle function, results showed that Calcipotriol restored grip strength in male SKO mice, increased muscle protein synthesis and mitochondrial biogenesis, while decreasing inflammation and atrogenes expression
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