There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Ferroptosis is a non-apoptotic and iron-dependent form of regulated cell death. Ferroptosis is characterized by extensive lipid peroxidation, which can be suppressed by iron chelators or lipophilic antioxidants. CIL56 acts as a potent ferroptosis inducer with novel scaffold. CIL56 showed some degree of selectivity towards oncogenic-RAS-expressing cells in the BJ series. CIL56 induced iron-dependent ROS (reactive oxygen species). CIL56 was capable of engaging two independent death pathways: ferroptosis at low concentrations, and a necrotic, non-suppressible phenotype at higher concentrations. Antioxidants and iron chelators only suppressed the lethality of low concentrations of CIL56[1]. Two clonal ACACA (acetyl-CoA carboxylase alpha; encoding ACC1) null HT-1080 cells lines lacked ACC1 expression and exhibited 5-fold resistance to CIL56. Furthermore, the lethality of CIL56 was suppressed by the small molecule ACC1 inhibitor. These results suggest that CIL56 triggers cell death dependent upon the rate-limiting de novo lipid synthetic enzyme ACC1[2].
CIL56 细胞实验
Cell Line
Concentration
Treated Time
Description
References
KBM7 cells
5.5 µM
10 to 21 days
To investigate the mechanism of CIL56-induced nonapoptotic cell death, results showed that CIL56-induced cell death is dependent on the lipid metabolism gene ACACA.
ACS Chem Biol. 2015 Jul 17;10(7):1604-9.
Neonatal cardiomyocytes
1 µM
24 hours
To evaluate the effect of CIL56 on promoting proliferation of NRCMs.
J Cell Physiol. 2022 May;237(5):2539-2549.
HT-1080 cells
6.5 µM
24 hours
To study the effect of CIL56 on the metabolism of HT-1080 cells, results showed that CIL56 treatment significantly altered lipid metabolism in cells.
ACS Chem Biol. 2015 Jul 17;10(7):1604-9.
HT-1080 cells
6.5 µM
8 hours
CIL56 treatment significantly altered levels of metabolites, suggesting it induces metabolic changes linked with cell death.
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